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undergraduate thesis
Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. urn:nbn:hr:149:781037
Kalčec, Nikolina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Kalčec, N. (2016). Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:781037

Kalčec, Nikolina. "Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:781037

Kalčec, Nikolina. "Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:781037

Kalčec, N. (2016). 'Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:781037

Kalčec N. Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2016 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:781037

N. Kalčec, "Derivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:149:781037

Metadata
TitleDerivati benzopirona s potencijalnim antioksidativnim djelovanjem: sinteza i strukturna karakterizacija
Title (english)Benzopirone derivatives with potential antioxidant activity: synthesis and structural characterization
AuthorNikolina Kalčec
MentorTatjana Gazivoda Kraljević (mentor)
Committee memberTatjana Gazivoda Kraljević (predsjednik povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2016-07-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
U ovom radu prikazana je sinteza, strukturna i spektroskopska karakterizacija novih 7-hidroksi-4-metil derivata kumarina supstituiranih u položaju C-3 (hidroksi/metoksifenil) etinilnim supstituentom u svrhu ispitivanja njihovog antioksidativnog djelovanja. Sonogashira-inom reakcijom unakrsnog povezivanja 7-hidroksi-3-klor-4-metilkumarina i 2-metoksifeniletina ili 3-hidroksifeniletina uz tetrakistrifenilfosfin paladij kao katalizator, CuI kao kokatalizator i uz bazu Et3N pripravljeni su spojevi 1 i 2. Strukturna i spektroskopska karakterizacija novosintetiziranih spojeva 1 i 2 provedena je 1H- i 13C-NMR, UV/Vis i fluorimetrijskom spektroskopijom. Farmakološki učinci i moguće biološke mete novopripravljenih spojeva predviđene su in silico analizom (PASS). Antiosidativna aktivnost novosintetiziranih spojeva ispitat će se cikličkom voltametrijom.
Abstract (english)
This work presents the synthesis, structural and spectroscopic characterization of novel 7-hidroxy-4-methylcoumarin derivatives substituted in position C-3 with (hydroxy/methoxyphenyl)ethynyl substituent in order to determine their antioxidant activity. Sonogashira cross-coupling reaction of 3-chloro-7-hydroxy-4-methylcoumarin and 2-methoxyphenylethyne or 3-methoxyphenylethyne with tetrakistriphenylphosphine palladium as a catalyst, CuI as a cocatalyst and Et3N as a base compounds 1 and 2 were obtained. The structural and spectroscopic characterization of new synthesized compounds 1 and 2 was conducted by 1H- and 13C-NMR, UV / Vis and fluorimetric spectroscopy. Pharmacological effects and possible biological targets of novel compounds are predicted by in silico analysis (PASS). The antioxidant activity of new synthesized compounds will be tested by cyclic voltammetry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:781037
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-04 13:37:43