Technology of adhesive development for medical applications is mostly used in dental medicine. Manufactured adhesives are used for creating a complete and lasting adhesion with tooth tissue along with antibacterial protection. Their task is not only health benefit but also aestheetics. Dentine adhesives become indispensable for number of procedures: creating composite fillings, composite and ceramic inlays, repairing fractured teeth and expanding natural ones, fixing ceramic crowns and veneers, creating bridges etc. Role of dentin bonding agents is to join two materials of different qualities - hydrophobic filling and moist dentin. Adhesives generate a chemical bond with the filling, while creating a micromechanical bond with the marginal tissue, with some creating a chemical one as well. This article gives an overview of dentin adhesives and their application. Experiments with two different types of dentin materials were done: composite (A) which is used in dental tissues restoration, and adhesive (B) which is used to bond dentine and enamel. Structural and surface properties of composite and adhesive samples were investigated, tests were done using FTIR-ATR spectroscopy and contact angle measurements. Thermal properties were determined using differential scanning calorimetry (DSC) and thermogravimetric analysis (B). Calculation of adhesion parameters was used for quantitative assessment of composite/adhesive interactions.