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undergraduate thesis
Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2015. urn:nbn:hr:149:558486
Boček, Ida
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Boček, I. (2015). Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:558486

Boček, Ida. "Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2015. https://urn.nsk.hr/urn:nbn:hr:149:558486

Boček, Ida. "Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2015. https://urn.nsk.hr/urn:nbn:hr:149:558486

Boček, I. (2015). 'Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:558486

Boček I. Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2015 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:149:558486

I. Boček, "Novi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:149:558486

Metadata
TitleNovi hidroksi supstituirani derivati benzamida kao potencijalni antioksidansi
Title (english)Novel hydroxy substituted benzamide derivatives as potential antioxidans
AuthorIda Boček
MentorMarijana Hranjec (mentor)
Committee memberMarijana Hranjec (predsjednik povjerenstva)
Committee memberNataša Perin (član povjerenstva)
Committee memberMirjana Novak Stankov (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2015-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
U okviru ovog rada predviđena je sinteza novih hidroksi supstituiranih derivata benzamida kao potencijalnih antioksidansa. Prema ranijim istraživanjima derivati benzamida imaju širok spektar biološkog djelovanja te se i dalje intenzivno istražuju. Za pripravu ciljanih molekula korištene su klasične metode organske sinteze. Višestupnjevitom linearnom sintezom priređeni su odgovarajući prekursori, 2-amino-5-cijanobenzimidazol 6 i 2-amino-6- cijanobenzotiazol 19. Kondenzacijom 2,4-dimetoksibenzoil-klorida 14 i odgovarajućeg amina priređen je 2,4-dimetoksi-N-(6-cijanobenzotiazol-2-il)benzamid 21. Nakon djelomično uspješnog uklanjanja zaštitnih skupina, Pinnerovom reakcijom priređen je 2-hidroksi-4- metoksi-N-[6-(2-imidazolinil)-benzotiazol-2-il)]benzamid 26. Tijek Pinnerove reakcije praćen je IR spektroskopijom. Strukture priređenih spojeva potvrđene su 1H i 13C NMR spektroskopijom.
Abstract (english)
The aim of this study was the synthesis of novel hydroxy substitued benzamide derivatives as a potential antioxidans. According to previous research, benzamide derivatives have a broad spectrum of biological activities and therefore are a subject of intensive scientific research. Classical organic chemistry methods were used for preparation of targeted compounds. Required precursors, 2-amino-5-cyanobenzimidazole 6 i 2-amino-6-cyanobenzotiazole 19 were prepared by using multi-step linear synthesis. In the condensation of 2,4- dimethoxybenzoil-chloride 14 and corresponding amine, 2,4-dimethoxy-N-(6- cyanobenzothiazol-2-yl)benzamide 21 was prepared. After the partial successful removal of protection groups, 2-hydroxy-4-methoxy-N-[6-(2-imidazolinyl)-benzothiazol-2-yl)]benzamide 26 was prepared in the Pinner reaction. The Pinner reaction was monitored by IR spectroscopy. The structures of all newly prepare compounds were confirmed by means of 1H and 13C NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:558486
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Environmental chemistry and green technologies
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2016-09-16 13:30:33