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undergraduate thesis
Razvoj i validacija kromatografske metode za određivanje alendronata
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. urn:nbn:hr:149:836207
Borković, Ivana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Borković, I. (2016). Razvoj i validacija kromatografske metode za određivanje alendronata (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:836207

Borković, Ivana. "Razvoj i validacija kromatografske metode za određivanje alendronata." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:836207

Borković, Ivana. "Razvoj i validacija kromatografske metode za određivanje alendronata." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:836207

Borković, I. (2016). 'Razvoj i validacija kromatografske metode za određivanje alendronata', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:836207

Borković I. Razvoj i validacija kromatografske metode za određivanje alendronata [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2016 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:836207

I. Borković, "Razvoj i validacija kromatografske metode za određivanje alendronata", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:149:836207

Metadata
TitleRazvoj i validacija kromatografske metode za određivanje alendronata
Title (english)Development and validation of chromatographic method for the determination of alendronate
AuthorIvana Borković
MentorSandra Babić (mentor)
Committee memberSandra Babić (predsjednik povjerenstva)
Committee memberMirta Čizmić (član povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2016-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
Mnogi farmaceutici i proizvodi za osobnu higijenu danas su prepoznati kao potencijalna zagađivala okoliša diljem svijeta. Skupina antibiotika, poznata kao bisfosfonati danas predstavljaju zlatni standard u liječenju osteoporoze. Zbog učestale primjene i potrošnje u velikim količinamate fizikalno-kemijskih svojstava poput dobre topljivosti u vodi, potencijalno mogu doći u sve djelove okoliša. Kada dođu u okoliš, farmaceutici podliježu biotičkim i abiotičkim procesima koji rezultiraju smanjenjem komcentracije osnovne molekule farmaceutika i nastankom razgradnih produkata. Kako bi se moglo razumjeti ponašanje farmaceutika u okolišu, neophodne su analitičke metode koje omogućuju njihovo praćenje u okolišu. Cilj ovog rada je upoznati se s analitičkim metodama određivanja alendronata, farmaceutika iz skupine bisfosfonata. Na temelju dostupne literature može se reći da je metoda za određivanje alendronata tekućinska kromatografija visoke djelotvornosti vezana s fluorescentnim detektorom ili spektrometrijom masa. U radu je dan pregled metoda određivanja alendronata te njihova usporedba na temelju izvedbenih značajki određenih tijekom validacije metode.
Abstract (english)
Many pharmaceuticals and personal care products are being recognized as potential environmental risk around the world. Bisphosponates are group of pharmaceuticals that are being used in treating bone disorders such as osteoporosis. Because of their high consumption rate and their physico–chemical properties, such as high water solubility, they can potentially reach every segment of the environment. Once in the environment, pharmaceuticals undergo biotic and abiotic processes that result in decrease of the main compound and in emergence of degradation products. In order to understand the behavior of pharmaceuticals in the environment it is necessary to develop analytical methods that can be used for their monitoring in the environment. Analytical methods for determining alendronat, bisphosponate pharmaceutical, are being presented in this work. Based on literature overview the optimal chromatographic method proved to be high performance liquid chromatography (HPLC) coupled to fluorescent detector or mass detector. The presented methods were compared based on validation parameters determined during their validation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:836207
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-02-06 13:20:13