Today people use more and more pharmaceutical products. Given that pharmaceuticals are partially dissolved in organisms of humans and animals, there concentration in the environment rises and poses a threat to it, but also for people. The compound estrogen 17β-estradiol (E2) causes changes in the endocrine systems of living organisms and is therefore undesirable to be found in the environment. Hence, the European Union listed the compound as potentially harmful and that it should be monitored din the environment. Current technologies for waste water treatment aren’t fully able to successfully remove pharmaceutical micro pollutants, or in other words the latest priority compounds, therefore new methods are needed. A possible alternative or supplement for conventional treatment methods are oxidation process on which more research is being conducted today. This article assesses the possibility of using photocatalytic degradation on E2 in water with a solar/TiO2-FeZSM5/H2O2 process. The effects of the proposed process were tested on these parameters: initial pH value, concentration of hydrogen peroxide and concentration of catalysts (zeolite ZSM5 type with interchangeable iron ions FeZSM5); to assess the degradation of E2. To determine the optimal values of parameters in the process by which the level of degradation will be at its highest, the Box-Behnken experiment design with process parameters. Experiments have shown that all examined process parameters affect the degradation kinetics but the amount of FeZSM5 proved to be the determining factor in the experimental process. The optimal conditions are as follows: the optimal amount of FeZSM5 in the catalyst is 33,36%, the pH value of the solution at 5,5 and [H2O2] = 50 mM. The aforementioned conditions achieve the highest degradation rate of 17β-estradiol.