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undergraduate thesis
Kinetički modeli u farmaceutskoj industriji
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. urn:nbn:hr:149:973986
Milićević, Andrea
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Milićević, A. (2016). Kinetički modeli u farmaceutskoj industriji (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:973986

Milićević, Andrea. "Kinetički modeli u farmaceutskoj industriji." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:973986

Milićević, Andrea. "Kinetički modeli u farmaceutskoj industriji." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:973986

Milićević, A. (2016). 'Kinetički modeli u farmaceutskoj industriji', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:973986

Milićević A. Kinetički modeli u farmaceutskoj industriji [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2016 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:149:973986

A. Milićević, "Kinetički modeli u farmaceutskoj industriji", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:149:973986

Metadata
TitleKinetički modeli u farmaceutskoj industriji
Title (english)Kinetic modeling in pharmaceutical industry
AuthorAndrea Milićević
MentorGordana Matijašić (mentor)
Committee memberGordana Matijašić (predsjednik povjerenstva)
Committee memberKrunoslav Žižek (član povjerenstva)
Committee memberIgor Dejanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2016-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
In vitro ispitivanje oslobađanja djelatne tvari nalazi sve veću primjenu u farmaceutskoj industriji pri razvitku kako inovativnih, tako i generičkih lijekova. Djelatna tvar može se oslobađati difuzijskim mehanizmom ili erozijom, te može imati trenutni, produženi ili kontrolirani učinak. Ispitivanje se provodi propisanim metodama, specifičnim za svaku djelatnu tvar. Rezultati se opisuju statističkim metodama, metodama neovisnima o modelu te metodama ovisnima o modelima. U ovom radu ispitano je otpuštanje lijeka za reguliranje srčane aritmije, dronedaron hidroklorida, iz dva različita pripravka: mikrokapsula dobivenih sušenjem raspršivanjem u kojima je dronedaron obložen arapskom gumom, te peletama pripremljenim od mikrokristalne celuloze na koje je dronedaron nanesen impregnacijom u vakuumu. Prema rezultatima ispitivanja, otpuštanje dronedarona s obje vrste pripravka može se prikladno opisati Weibullovim modelom. Također, profil otpuštanja dronedarona iz mikrokapsula serije GA 60 pokazao se najsličniji profilu otpuštanja dronedarona iz komercijalnih Multaq tableta što pokazuje njihov potencijal kao nosača dronedaron hidroklorida.
Abstract (english)
In vitro release of the active substance is commonly used in the pharmaceutical industry in the development of both, innovative and generic drug. The active substance can be released by a diffusion mechanism or erosion mechanism and can have immediate, delayed or controlled release. Dissolution test are carried out according to prescribed methods, specific for each active substance and described in the pharmacopoeia. The results are described using statistical methods, model independent methods and model dependent methods. In this study the release of dronedarone hydrochloride, drug for regulation of cardiac arrhythmia, was investigated using two different formulations: microcapsules obtained by spray-drying were coated with gum arabic, and the pellets prepared from microcrystalline cellulose and impregnated in vacuum with dronedarone. According to test results, the release profiles of the drug, for both formulations, can be described using the Weibull model. Also, the release profile of the microcapsules GA 60 proved to be most similar to the release profile of the commercial Multaq tablets which shows their potential as dronedarone carrier.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:973986
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-02-19 12:19:58