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master's thesis
Kontrola oblika kristala u postupku šaržne kristalizacije
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:137345
Ždrakić, Marija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Ždrakić, M. (2017). Kontrola oblika kristala u postupku šaržne kristalizacije (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:137345

Ždrakić, Marija. "Kontrola oblika kristala u postupku šaržne kristalizacije." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:137345

Ždrakić, Marija. "Kontrola oblika kristala u postupku šaržne kristalizacije." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:137345

Ždrakić, M. (2017). 'Kontrola oblika kristala u postupku šaržne kristalizacije', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:137345

Ždrakić M. Kontrola oblika kristala u postupku šaržne kristalizacije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:149:137345

M. Ždrakić, "Kontrola oblika kristala u postupku šaržne kristalizacije", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:137345

Metadata
TitleKontrola oblika kristala u postupku šaržne kristalizacije
Title (english)Crystals shape control in batch crystallization
AuthorMarija Ždrakić
MentorJasna Prlić Kardum (mentor)
Committee memberJasna Prlić Kardum (predsjednik povjerenstva)
Committee memberAleksandra Sander (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
Kristalizacija kao jedan od važnijih procesa farmaceutske industrije podliježe razvitku novih tehnika u dizajnu čestica. Kao jedno od područja aktivnog istraživanja farmaceutske industrije pojavila se sferična kristalizacija zbog činjenice da omogućuje istovremenu aglomeraciju kristala i kristalizaciju. U ovom radu, u okviru šaržne kristalizacije, istraživan je utjecaj sustava (otapalo, antiotapalo, sredstvo za premošćivanje) na granulometrijska svojstva (veličinu i oblik) i strukturu nastalih kristala dronedaron-hidroklorida koji je aktivna komponenta lijeka za liječenje srčane aritmije. Odabirom pogodnog sustava pokušao se provesti postupak sferične kristalizacije. Nakon određivanja krivulja topljivosti provedena je kristalizacija za dva različita sustava koji su utjecali na veličinu i oblik kristala, ali ne i na strukturu. Nakon završetka procesa, oblik kristala praćen je svjetlosnim i stereo mikroskopom, dok je brzina otpuštanja dronedaron-hidroklorida praćena uređajem Dissolution tester RC-6D.
Abstract (english)
In the pharmaceutical industry, the process of crystallization as one of the most important process, is subject of development of new techniques in particle design. Spherical crystallization has emerged as one of the areas of active research in the pharmaceutical industry. Spherical crystallization is a particle design technique, by which crystallization and agglomeration can be carried out simultaneously in one step. In this study, through the batch crystallization process, the effect of the system (solvent, antisolvent, bridging liquid) on the granulometric properties (size and form) and the structure of formed dronedarone-hydrochloride crystals, which is an active component of the drug for the treatment of cardiac arrhythmia, was investigated. After the selection a suitable system, the spherical crystallization process is carried out. Solubility of the salt has also been determined and the crystallization for two different systems was performed. It was found that the addition of different solvents affects the shape and the crystal size distribution, but not crystals structure. The shape of crystals was monitored with light and stereo microscope and the rate of release of dronedarone-hydrochloride was determined by the Dissolution tester RC-6D.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:137345
Study programmeTitle: Environmental Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka ekoinženjerstva (magistar/magistra inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-21 13:19:16