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master's thesis
Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:911850
Zorić, Ivana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Zorić, I. (2017). Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:911850

Zorić, Ivana. "Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:911850

Zorić, Ivana. "Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:911850

Zorić, I. (2017). 'Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:911850

Zorić I. Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:911850

I. Zorić, "Granuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:911850

Metadata
TitleGranuliranje u fluidiziranom sloju taljenjem: usporedni studij in-situ metode i metode raspršivanjem
Title (english)Fluidized bed melt granulation: a comparative study of in-situ and spray-on method
AuthorIvana Zorić
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberGordana Matijašić (član povjerenstva)
Committee memberMirela Leskovac (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
U sklopu ovog istraživanja provedeno je okrupnjavanje praškaste mješavine saharoze (pomoćna tvar) i azitromicin dihidrata (djelatna tvar), primjenom tehnologije granuliranja u fluidiziranom sloju taljenjem. Eksperimenti granuliranja provedeni su primjenom dviju metoda doziranja veziva: metodom raspršivanja (engl. spray-on method) s gornjeg i donjeg položaja te in-situ metodom. Vezivna tvar korištena u okviru ovog istraživanja je gliceril monostearat (GMS). Studij fenomena okrupnjavanja u laboratorijskom mjerilu usmjeren je k pronalaženju optimalnih uvjeta provedbe procesa, načina doziranja veziva i svojstava ulaznih struja materijala koji će sinergističkim djelovanjem upravljati mikro- i mezorazinskim događajima na povoljan i željeni način te time rezultirati kolektivom postojanih okrupnjenih jedinki, granula saharoze u čiju je matricu ugrađena djelatna tvar, azitromicin dihidrat. Određene raspodjele veličina čestica ispitivanih granulata ukazuju na uspješnu fizičku pretvorbu tvari (okrupnjavanje) saharoze i djelatne tvari, azitromicin dihidrata, tijekom procesa granuliranja. Važno traženo svojstvo pripremljene mješavine za tabletiranje je ujednačenost ciljanog sadržaja djelatne tvari u matrici granula neovisno o njihovoj veličini. UV/VIS spektrofotometrijska analiza korištena je pri određivanju sadržaja djelatne tvari u ispitivanim granulatima. Određeni sadržaj djelatne tvari je zadovoljavajući u svim ispitivanim veličinskim razredima.
Abstract (english)
Within this study, enlargement of powdered saccharose (excipient) and azythromycin dihydrate (active pharmaceutical ingredient) mixture using fluidized bed melt granulation has been conducted. Granulation experiments have been carried out using two binder dosing methods: spray-on method (top-spray and bottom-spray positions) and in-situ method. Binder used within this research was glyceril monostearate (GMS). Study of the enlargement phenomenon in a lab-scale is focused towards detection of process conditions, binder dosing method and formulation properties that will synergically drive micro- and meso-scale events in a favourable and desired way and therewith result in a collective of stable enlarged entities, saccharose granule in which the active substance, azithromycin dihydrate, is incorporated into the matrix. Detected particle size distributions of all tested granulates indicate a successful physical conversion (enlargement) of sucrose and active substance, azithromycin dihydrate, during granulation process. An important tabletting mixture property is uniformity of the desired active substance content, azithromycin dihydrate, in the granule matrix. UV/VIS spectrophotometric analysis has been used to determine the active substance content in all observed granulates. Determined active substance content in all size fractions proved to be satisfactory.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:911850
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-04-30 13:10:37