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master's thesis
Priprema raspadljivih tableta za usta primjenom liofilizacije
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:347383
Gavran, Iva
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Gavran, I. (2018). Priprema raspadljivih tableta za usta primjenom liofilizacije (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:347383

Gavran, Iva. "Priprema raspadljivih tableta za usta primjenom liofilizacije." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:347383

Gavran, Iva. "Priprema raspadljivih tableta za usta primjenom liofilizacije." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:347383

Gavran, I. (2018). 'Priprema raspadljivih tableta za usta primjenom liofilizacije', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 17 June 2024, https://urn.nsk.hr/urn:nbn:hr:149:347383

Gavran I. Priprema raspadljivih tableta za usta primjenom liofilizacije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 June 17] Available at: https://urn.nsk.hr/urn:nbn:hr:149:347383

I. Gavran, "Priprema raspadljivih tableta za usta primjenom liofilizacije", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:347383

Metadata
TitlePriprema raspadljivih tableta za usta primjenom liofilizacije
Title (english)Preparation of orally disintegrating tablets using lyophilization
AuthorIva Gavran
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberIrena Škorić (član povjerenstva)
Committee memberAnamarija Rogina (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
U okviru ovog istraživanja pripremljene su raspadljive minitablete za usta s djelatnom tvari, Lurasidon hidrokloridom. Karakterizira ju loša topljivost, a time i loša bioraspoloživost lijeka. Topljivost se nastojala povećati pripremom čvrste disperzije primjenom liofilizacije, odnosno sušenja smrzavanjem pri čemu se djelatna tvar nastojala ugraditi u hidrofilnu polimernu matricu, polietilen glikola 4000. Tri uzorka s različitim udjelima djelatne i pomoćne tvari tretirana su liofilizacijom. Dobiveni liofilizati karakterizirani su sadržajem vlage, diferencijalnom pretražnom kalorimetrijom, rendgenskom difrakcijskom praha i infracrvenom spektroskopijom. Pripremljene su četiri formulacije lijeka primjenom procesnih tehnologija liofilizacije, granuliranja i tabletiranja. Tri formulacije lijeka pripravljene su s liofilizatima Lurasidon hidroklorida i polietilen glikola te granulatom pomoćnih tvari, dok je četvrta pripremljena granuliranjem djelatne tvari i pomoćnih tvari u fluidiziranom sloju in situ taljenjem. Korištene pomoćne tvari su manitol, natrij kroskarmeloza i magnezijev stearat. Navedene formulacije korištene su za izradu minitableta promjera 3 mm. Provedena je karakterizacija minitableta ispitivanjem ujednačenosti masa tableta, raspadljivosti tableta, i ispitivanjem sadržaja djelatne tvari u tabletama te profila otpuštanja djelatne tvari.
Abstract (english)
Within this study, orally disintegrated mini-tablets with Lurasidone hydrochloride drug were prepared. It is characterized by poor solubility and thus low drug bioavailability. Solubility is attempted to increase by preparation of solid dispersion using lyophilization or freeze-drying, whereby the drug is attempted to be embedd in a hydrophilic polymer matrix of polyethylene glycol 4000. Three samples with different ratios of drug and excipient were treated by lyophilization. Derived lyophilisates were characterized by moisture content, differential scanning calorimetry, X-ray powder diffraction and infrared spectroscopy. Four drug formulations were prepared using process technologies of lyophilization, granulation and tabletting. Three drug formulations were prepared with lyophilisates of Lurasidone hydrochloride and polyethylene glycol, and using granulate of excipients, while the fourth formulation was prepared by granulation of drug and excipients in fluidized bed by in situ melting. Excipients used were mannitol, sodium croscarmellose and magnesium stearate. Mentioned formulations were used to produce mini-tablets of 3 mm in diameter. Characterization of mini-tablets is carried out by testing the tablet mass uniformity, tablet disintegration, and by studying the drug content in tablets and drug release profiles.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:347383
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-11-03 09:50:29