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undergraduate thesis
Sinteza O-alkiliranih derivata 4-kinolinona
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:618183
Šimek, Helena
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Šimek, H. (2017). Sinteza O-alkiliranih derivata 4-kinolinona (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:618183

Šimek, Helena. "Sinteza O-alkiliranih derivata 4-kinolinona." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:618183

Šimek, Helena. "Sinteza O-alkiliranih derivata 4-kinolinona." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:618183

Šimek, H. (2017). 'Sinteza O-alkiliranih derivata 4-kinolinona', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:618183

Šimek H. Sinteza O-alkiliranih derivata 4-kinolinona [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:618183

H. Šimek, "Sinteza O-alkiliranih derivata 4-kinolinona", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:618183

Metadata
TitleSinteza O-alkiliranih derivata 4-kinolinona
Title (english)Synthesis of O-alkylated 4-quinolinone derivatives
AuthorHelena Šimek
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberAndrijana Meščić Macan (član povjerenstva)
Committee memberŠime Ukić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-07-10, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Cilj ovoga rada bio je sintetizirati nove spojeve bazirane na konjugatima 4-kinolinona i ferocena povezanih 1,2,3-triazolnom poveznicom, s potencijalnim antimikrobnim i citostatskim djelovanjem. 6-Supstituirani-4-(2-brometoksi)kinolinoni (2a-2d) dobiveni su reakcijom O-alkiliranja s dibrometanom u prisustvu baze. Bakrom(I) kataliziranom 1,3-dipolarnom cikloadicijom etinil-ferocena i azidnih derivata kinolinona (3a-3d) sintetizirani su ciljani ferocenil-kinolinon hibridi (4a-4d). Strukture spojeva potvrđene su 1H- i 13C- NMR spektroskopijom.
Abstract (english)
The aim of this work was to synthesize novel 1,2,3-triazolyl tethered 4-quinolone-ferrocene conjugates as potential new antimicrobial and cytostatic agents. 6-Substituted-4-(2-(bromoethoxy)quinolones (2a-2d) were synthesized by O-alkylation reaction with dibromoethane in the presence of a base. The targeted ferrocenyl–quinolone hibrids (4a-4d) were prepared via copper(I) catalyzed 1,3-dipolar cycloaddition of ethynyl ferrocene and azido quinolone derivatives (3a-3d). The structures of synthesized compounds have been confirmed by 1H- and 13C-NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:618183
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-12-15 12:45:16