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undergraduate thesis
Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:388870
Topalović, Ines
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Topalović, I. (2017). Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:388870

Topalović, Ines. "Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:388870

Topalović, Ines. "Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:388870

Topalović, I. (2017). 'Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:388870

Topalović I. Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:149:388870

I. Topalović, "Hidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:388870

Metadata
TitleHidrolitička i fotolitička razgradnja hidroksiklorokina u okolišu
Title (english)Hydrolytic and photolytic degradation of hydroxychloroquine in the environment
AuthorInes Topalović
MentorSandra Babić (mentor)
Committee memberSandra Babić (predsjednik povjerenstva)
Committee memberIrena Škorić (član povjerenstva)
Committee memberMirta Čizmić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
Proizvodnja i potrošnja farmaceutika raste, a zbog toga je i njihova koncentracija u okolišu sve veća. Pod utjecajem različitih čimbenika iz okoliša te ovisno o fizikalno-kemijskim svojstvima samih farmaceutika, dolazi do njihove razgradnje pri čemu mogu nastati toksični produkti. Stoga je veoma bitno promatrati razgradnju farmaceutika u okolišu. Cilj ovoga rada bio je proučiti hidrolitičku i fotolitičku razgradnju hidroksiklorokina koje pripadaju abiotičkim procesima. Tijek hidrolitičke i fotolitičke razgradnje praćen je tekućinskom kromatografijom visoke djelotvornosti vezanoj s detektorom s nizom dioda (HPLC-DAD). Hidrolitička razgradnja hidroksiklorokina istražena je u ultračistoj vodi pri tri različite pH-vrijednosti (4, 7 i 9) te je uočeno da hidroksiklorokin ne hidrolizira. Fotolitička razgradnja ispitana je u ultračistoj i izvorskoj vodi te je uočeno da je razgradnja brža u izvorskoj vodi. Osim toga, praćen je i utjecaj pH-vrijednosti na fotolitičku razgradnju i to na dva načina, u puferskim otopinama koje se opiru promjeni pH-vrijednosti i s pH-vrijednostima podešenim napočetku eksperimenta (4, 7, 9 i 10) jer prilikom razgradnje dolazi do promjene pH-vrijednosti. Uočeno je da povišenjem pH-vrijednosti, raste brzina fotolitičke razgradnje, odnosno da se smanjuje vrijeme poluraspada. Također, uočeno je da razgradnjom hidroksiklorokina nastaju dva razgradna produkta.
Abstract (english)
Production and consumption of pharmaceuticals increase and because of that their concentration in the environment is also getting bigger. Under the influence of different environmental factors and depending on physico-chemical properties of pharamceuticals; pharmaceuticals degrade. Toxic products can arise during degradation of pharmaceuticals so it is very important to examine their degradation. The aim of this work was to examine abiotic processes, hydrolytic and photolytic degradation, of hydroxychloroquine. The rate of hydrolytic and photolytic degradation was monitored by high performance liquid chromatography with diode array detection (HPLC-DAD). Hydrolytic degradation of hydroxychloroquine was performed in ultra-pure water at three pH-values (4, 7 and 9) and it was noticed that hydroxychloroquine did not hydrolyze. Photolytic degradation was performed in ultra-pure and spring water and it was noticed that degradation was faster in spring water. Furthermore, the impact of pH-values on photolytic degradation was monitored in two ways: (i) in buffer solutions that resist change of pH-values and (ii) in solutions with a preset pH-values (4, 7, 9 and 10) because during degradation pH-values change. By increasing the pH-value, the rate of degradation was increased and half-life time decreased. During degradation of hydroxychloroquine, formation of two degradation products were observed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:388870
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2021-01-05 12:26:55