prikaz prve stranice dokumenta Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera
  Download
PDF 1.32 MB
undergraduate thesis
Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:953225
Novak, Mateja
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Novak, M. (2017). Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:953225

Novak, Mateja. "Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:953225

Novak, Mateja. "Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:953225

Novak, M. (2017). 'Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:953225

Novak M. Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:953225

M. Novak, "Sinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:953225

Metadata
TitleSinteza i strukturna karakterizacija novih ferocenskih derivata 7-deazapurina kao potencijalnih elektrokemijskih markera
Title (english)Synthesis and structural characterization of novel ferrocene 7-deazapurine derivatives as potential electrochemical markers
AuthorMateja Novak
MentorTatjana Gazivoda Kraljević (mentor)
Committee memberTatjana Gazivoda Kraljević (predsjednik povjerenstva)
Committee memberSvjetlana Krištafor (član povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Cilj ovog rada bila je sinteza novih derivata purina i 7-deazapurina s ferocenskim supstituentom te njihova strukturna karaktrizacija i elektrokemijska ispitivanja. Reakcijom N-alkiliranja purinskog ili 7-deazapurinskog prstena s odgovarajućim 1,4-dihalo-but-2-enom ili propargil-bromidom uz NaH kao bazu u DMF-u pripravljeni su N-9-butenilni derivati 7-deazapurina (1 i 5) i propargilni derivati 7-deazapurina (2) i purina (3 i 4). Pd-kataliziranom Sonogashira-inom reakcijom unakrsnog spajanja 6-klor-N-9-propargilpurina (3) s etinilferocenom sintetiziran je 6-(2-ferocenetinil)-9-(prop-2-in-1-il)purin (6). Strukturna karakerizacija purinskih i 7-deazauprinskih derivata provedena je 1H NMR spektroskopijom. Elektrokemijska ispitivanja spojeva 3 i 6 provedena su cikličkom voltametrijom.
Abstract (english)
The aim of this study was to synthesize the novel purine and 7-deazapurine derivatives with ferrocenyl supstituent and their structural characterization and electrochemical evaluation. N-alkylation reaction of purine or 7-deazapurine ring with corresponding 1,4-dihalo-but-2-enes or propargyl bromide in the presence of NaH as base in DMF N-9-butenyl derivatives of 7-deazapurine (1 i 5) and propargyl derivatives of 7-deazapurine (2) and purine (3 and 4). Pd-catalysed Sonogashira cross-coupling reaction of 6-chloro-N-9-propargylpurine (3) with ethynyl ferrocene gave 6-(2-ferrocene ethynyl)-9-(prop-2-yn-1-yl) purine (6). Structural characterization of purine and 7-deazapurine derivatives was performed using 1H NMR spectroscopy. Electrochemical evaluation of compounds 3 and 6 was performed by cyclic voltammetry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:953225
Study programmeTitle: Environmental Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-03-11 12:58:15