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undergraduate thesis
Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:636105
Kapitanović, Angela
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Kapitanović, A. (2017). Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:636105

Kapitanović, Angela. "Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:636105

Kapitanović, Angela. "Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:636105

Kapitanović, A. (2017). 'Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:636105

Kapitanović A. Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:636105

A. Kapitanović, "Amino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:636105

Metadata
TitleAmino- i nitro-supstituirani benzo[b]tieno[2,3-c]kinoloni kao potencijalni antioksidansi
Title (english)Amino- and nitro-substituted benzo[b]thieno[2,3-c]quinolones as potential antioxidants
AuthorAngela Kapitanović
MentorMarijana Hranjec (mentor)
Committee memberMarijana Hranjec (predsjednik povjerenstva)
Committee memberMaja Cindrić (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-09-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
okviru ovog rada priređeni su amino i nitro supstituirani derivati benzo[b]tieno[2,3-c]kinolona. Za pripravu ciljanih molekula korištene su klasične metode organske sinteze. Počevši od sinteze cimetnih kiselina 3a-b koje se prevode u odgovarajuće kloride 4a-b te njihovom kondenzacijom s anilinima dobivaju se nitro supstituirani amidi 6-8. Redukcijom nitro skupine spojeva 6-8 dobivaju se amino supstituirani amidi 12-14. Sinteza cikličkih derivata 9-11 i 15-17 provedena je fotokemijskom ciklizacijom acikličkih spojeva 6-8 te 12-14. Struktura priređenih spojeva potvrđena je korištenjem 1H i 13C NMR spektroskopije. Spojevi su dodatno spektroskopski okarakterizirani UV/Vid i fluorimetrijskom spektroskopijom, a provedene su i UV/Vid i fluorimetrijske titracije otopina spojeva s različitim otopinama metalnih soli ili u puferima različitog pH kako bi se utvrdila njihova mogućnost primjene kao senzora za određivanje kationa u otopinama ili za detekciju pH. Nekim priređenim derivatima ispitana je i antioksidativna aktivnost.
Abstract (english)
In this work, we describe the synthesis of novel amino and nitro substituted derivates of benzo[b]thieno[2,3-c]quinolones. For the preparation of target molecules classical methods of organic synthesis were used started from cimetic acids 3a-b which are converted to corresponding acyl-chlorides 4a-b which gave in the condensation with anilines targeted nitro substituted amides 6-8. Within the reduction of nitro derivatives 6-8, amino substituted amides 12-14 obtained. Cyclic derivatives 9-11 and 15-17 were prepared by using photochemical cyclization of acyclic molecules 6-8 and 12-14. The structure of synthesized molecules were confirmed by means of 1H i 13C NMR spectroscopy. Also, the synthesized molecules were additionally studied by UV/Vis and fluorimetric spectroscopy. Also, UV/Vis and fluorimetric titrations of aqueous compounds solutions with aqueous solutions of metal salts or with buffers with different pH were performed to explore their possible application as chemosensors or pH sensors. Some of prepared derivatives were tested for their antioxidative activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:636105
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2021-03-12 09:27:50