prikaz prve stranice dokumenta Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima
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undergraduate thesis
Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:278053
Komljenović, Katarina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Komljenović, K. (2017). Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:278053

Komljenović, Katarina. "Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:278053

Komljenović, Katarina. "Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:278053

Komljenović, K. (2017). 'Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:278053

Komljenović K. Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:149:278053

K. Komljenović, "Simulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:278053

Metadata
TitleSimulacija proizvodnje intermedijera za proizvodnju lijekova u različitim reaktorskim sustavima
Title (english)Simulation of pharmaceutical precursor production in different reactor types
AuthorKatarina Komljenović
MentorAna Vrsalović Presečki (mentor)
Committee memberAna Vrsalović Presečki (predsjednik povjerenstva)
Committee memberVesna Tomašić (član povjerenstva)
Committee memberJasna Prlić Kardum (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Reaction Engineering
Abstract
Statini predstavljaju skupinu lijekova sa sposobnošću snižavanja kolesterola LDL (engl. Low Density Lipoprotein; LDL) i lipoproteina male gustoće inhibiranjem HMG-CoA (3-hidroksi-3-metilglutaril-koenzimA) reduktaza. Inhibicija navedenog enzima je vrlo važna u sprečavanju bolesti poput hiperkolesterolemije, koronarne bolesti, srčanih te kardiovaskularnih bolesti. U radu je provedena simulacija sinteze 6-kloro-3,5-dihidroksi heksanala, (laktola) koji je bitan prekursor u dobivanju statina. Sinteza je provedena u reakciji dvostruke aldolne adicije acetaldehida i kloroacetaldehida katalizirane enzimom 2-deoksiriboza-5-fosfat aldolazom (DERA). Određena je kinetika svih reakcija koje se odvijaju tijekom sinteze laktola katalizirane enzimom DERA te su kinetike opisane Michaelis-Menteničinim izrazima. Postavljen je matematički model sinteze laktola u kotlastom reaktoru, kotlastom reaktoru s dotokom i protočno kotlastom reaktoru. U model je također uključena deaktivacija enzima uzrokovana prisutnosti aldehida koje imaju negativan utjecaj na stabilnost enzima, te je opisana kinetikom drugog reda. Na temelju dobivenih rezultata simulacije, uspoređeni su različiti početni uvjeti sinteze laktola u različitim tipovima reaktora.
Abstract (english)
Statins represents a group of medicines with the ability to lower cholesterol LDL and low density lipoproteins by inhibition HMG-CoA reductase (3-hydroxy-3-methylglutaryl-coenzyme A), which is very important in the prevention of diseases such as hypercholesterolemia, coronary diseases, cardiac and cardiovascular diseases. In this study the simulation of the synthesis of an important precursor of statin, (3R, 5R)-6-chloro-3,5-dihydroxyhexanal (lactone) was carried out. The synthesis was performed in the reaction of double aldol addition of acetaldehyde and chloroacetaldehyde catalyzed by the enzyme 2-deoxyribose-5-phosphate aldolase (DERA-e). The kinetics of all reactions that occurs during lactol synthesis catalyzed by DERA has been determined and kinetics was described by Michaelis-Menten equations. A mathematical model of lactol synthesis in batch reactor, fed-batch reactor and continuous tank flow reactor was established. The model also included the enzyme deactivation caused by the presence of various aldehydes that have a negative impact on the enzyme stability and was described by the second order kinetics. Based on the results of the simulation, the different initial conditions of lactol synthesis in different reactor mode were compared.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:278053
ProjectNumber: 635595
Title: Sustainable industrial processes based on a C-C bond-forming enzyme platform
Acronym: CARBAZYMES
Leader: Zvjezdana Findrik Blažević
Jurisdiction: eu
Funder: EC
Funding stream: H2020
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
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Created on2021-03-15 11:52:10