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undergraduate thesis
Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. urn:nbn:hr:149:122201
Kolman, Dora
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Kolman, D. (2017). Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:122201

Kolman, Dora. "Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:122201

Kolman, Dora. "Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:149:122201

Kolman, D. (2017). 'Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:122201

Kolman D. Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2017 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:122201

D. Kolman, "Kinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:149:122201

Metadata
TitleKinetika otpuštanja djelatne tvari iz granula dobivenih taljenjem u fluidiziranom sloju
Title (english)Dissolution kinetics of active pharmaceutical ingredient from granules obtained by melting in fluidized bed
AuthorDora Kolman
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberGordana Matijašić (član povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2017-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
Ovim istraživanjem sagledano je granuliranje u fluidiziranom sloju s in-situ taljenjem veziva kao moguća procesna tehnologija za pripravu mješavine azitromicin dihidrata i laktoze monohidrata pogodne za izradu tableta dobrih primjenskih svojstava. Dodatni ulazni procesni tokovi su zrak i čvrsti polietilen glikol (vezivo) čiji kolektiv kapljica nastaje in-situ taljenjem. Studij fenomena granuliranja u laboratorijskom mjerilu usmjeren je k pronalaženju uvjeta provedbe procesa, geometrije raspršivanja i svojstava ulaznih procesnih tokova koji će sinergističkim djelovanjem upravljati mikro- i mezorazinskim događajima na povoljan i željeni način te time rezultirati kolektivom postojanih okrupnjenih jedinki, granula laktoze monohidrata u čiju je matricu ugrađena djelatna tvar, azitromicin dihidrat. Uspješno granuliranje provedeno je in-situ taljenjem veziva. Dobiveni su kolektivi većih veličina čestica te izvrsne tecivosti. Spektrofotometrijskom analizom dokazana je uspješna ugradnja ciljanog sadržaja djelatne tvari u granulama veličinskog razreda 180-250 μm. Također, sagledani su profili otpuštanja djelatne tvari iz dobivenih granula.
Abstract (english)
With this study, fluidized bed granulation by in-situ binder melting is scrutinized as a potential process technology for preparation of azithromycin dihydrate and lactose monohydrate mixture that is suitable for manufacturing of tablets with good end-use properties. Additional inlet process streams are air and solid polyethylene glycol (binder), whose droplet population is formed using in-situ melting. Study of the granulation phenomenon in a lab-scale is focused towards detection of process conditions, spraying geometry and formulation properties that will synergically drive micro- and meso-scale events in a favourable and desired way and therewith result in a collective of stable enlarged entities, lactose monohydrate granule matrices in which the active substance, azithromycin dihydrate, is incorporated. Successful granulation is carried out for in-situ melting. Collectives of higher particle sizes and excellent flowability have been obtained. Efficient embedding of targeted active ingredient content in granules of size interval 180-250 μm has been proven using spectrophotometric analysis. Drug dissolution profiles of attained granules have been discussed as well.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:122201
Study programmeTitle: Environmental Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2021-06-10 12:05:35