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undergraduate thesis
Proučavanje sudbine peptidnih lijekova u okolišu
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:641550
Ivanković, Klaudija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Ivanković, K. (2018). Proučavanje sudbine peptidnih lijekova u okolišu (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:641550

Ivanković, Klaudija. "Proučavanje sudbine peptidnih lijekova u okolišu." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:641550

Ivanković, Klaudija. "Proučavanje sudbine peptidnih lijekova u okolišu." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:641550

Ivanković, K. (2018). 'Proučavanje sudbine peptidnih lijekova u okolišu', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:641550

Ivanković K. Proučavanje sudbine peptidnih lijekova u okolišu [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:149:641550

K. Ivanković, "Proučavanje sudbine peptidnih lijekova u okolišu", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:641550

Metadata
TitleProučavanje sudbine peptidnih lijekova u okolišu
Title (english)The environmental fate and behaviour of peptide therapeutics
AuthorKlaudija Ivanković
MentorSandra Babić (mentor)
Committee memberSandra Babić (predsjednik povjerenstva)
Committee memberMartina Biošić (član povjerenstva)
Committee memberIrena Škorić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
Peptidni lijekovi su nova generacija lijekova koja svoju ekspanziju na tržištu tek očekuje zbog dokazanih velikih prednosti u odnosu na dosadašnje lijekove. Općepoznati problem zagađenja okoliša konvencionalnim lijekovima zbog velike konzumacije i neadekvatnog odlaganja, mogao bi uskoro postati i problemom peptidnih lijekova. Dodatna problematika peptidnih lijekova u okolišu jest njihova izrazita biološka aktivnost. S obzirom da se radi o velikim molekulama koje sadrže kromoforne skupine, postoji mogućnost fotolitičke razgradnje, što dovodi do dodatne zabrinutosti po pitanju njihovih razgradnih produkata. U ovom radu ispitana je fotolitička razgradnja glikopeptidnog antibiotika vankomicina koji je trenutno najkorišteniji lijek iz skupine peptidnih lijekova zbog čega je izabran kao predstavnik. Fotolitička razgradnja pod utjecajem umjetnog Sunčevog zračenja praćena je u dvije vodene matrice, ultračistoj i izvorskoj vodi. Rezultati ukazuju da je vankomicin podložan fotolitičkoj razgradnji te da mu je vrijeme poluraspada oko 100 minuta. Analizom podataka nije uočena statistički značajna razlika između brzina fotodegradacije vankomicina u ultračistoj i izvorskoj vodi.
Abstract (english)
Peptide pharmaceuticals represent a new generation of pharmaceuticals which are expected to expand in the following years due to their great advantages over the currently used ones. As a consequence of excessive use and inadequate disposal, peptide pharmaceuticals could soon become the new lingering pollution problem, meeting the same well known fate of conventional pharmaceuticals. Peptide pharmaceuticals are known for their pronounced biological activities, which lead to additional threats to the environment. Their large molecular structures containing chromophores are likely to experience photolytic degradation, raising uncertainty about its byproducts. The main focus of this thesis is the photolytic degradation of the world’s most used peptide pharmaceutic, the vancomycin glycopeptide antibiotic. Photolytic degradation of vancomycin induced by artificial sunlight has been monitored in ultrapure and spring water matrices. Results have shown vancomycin to be prone to photolytic degradation, with its half-life of 100 minutes. After further analysis, there is no significant speed difference in vancomycin photodegradation between ultrapure and spring water.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:641550
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2021-06-23 11:16:42