prikaz prve stranice dokumenta Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju
  Download
PDF 1.55 MB
undergraduate thesis
Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:692890
Subotičanec, Valentino
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Subotičanec, V. (2018). Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:692890

Subotičanec, Valentino. "Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:692890

Subotičanec, Valentino. "Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:692890

Subotičanec, V. (2018). 'Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:692890

Subotičanec V. Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:149:692890

V. Subotičanec, "Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:692890

Metadata
TitleRaspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju
Title (english)Binder distribution in granules obtained by melting in fluidized bed
AuthorValentino Subotičanec
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberGordana Matijašić (član povjerenstva)
Committee memberVesna Ocelić Bulatović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
Ovim istraživanjem sagledano je granuliranje u fluidiziranom sloju s in-situ taljenjem veziva kao moguća procesna tehnologija za pripravu mješavine azitromicin dihidrata i laktoze monohidrata pogodne za izradu tableta dobrih primjenskih svojstava. Dodatni ulazni procesni tokovi su zrak i čvrsti polietilen glikol (vezivo) čiji kolektiv kapljica nastaje in-situ taljenjem. Studij fenomena granuliranja u laboratorijskom mjerilu usmjeren je k pronalaženju uvjeta provedbe procesa, geometrije raspršivanja i svojstava ulaznih procesnih tokova koji će sinergističkim djelovanjem upravljati mikro- i mezorazinskim događajima na povoljan i željeni način te time rezultirati kolektivom postojanih okrupnjenih jedinki, granula laktoze monohidrata u čiju je matricu ugrađena djelatna tvar, azitromicin dihidrat. Uspješno granuliranje provedeno je in-situ taljenjem veziva. Dobiveni su kolektivi većih veličina čestica te izvrsne tecivosti. Termogravimetrijskom analizom određen je sadržaj veziva u granulama različitih veličina. Također, sagledana je raspodjela sadržaja veziva među granulama različitih veličinskih razreda.
Abstract (english)
With this study, fluidized bed granulation by in-situ binder melting is scrutinized as a potential process technology for preparation of azithromycin dihydrate and lactose monohydrate mixture that is suitable for manufacturing of tablets with good end-use properties. Additional inlet process streams are air and solid polyethylene glycol (binder), whose droplet population is formed using in-situ melting. Study of the granulation phenomenon in a lab-scale is focused towards detection of process conditions, spraying geometry and formulation properties that will synergically drive micro- and meso-scale events in a favourable and desired way and therewith result in a collective of stable enlarged entities, lactose monohydrate granule matrices in which the active substance, azithromycin dihydrate, is incorporated. Successful granulation is carried out for in-situ binder melting. Collectives of higher particle sizes and excellent flowability have been obtained. Binder content has been detected in granules of different sizes using thermogravimetric analysis. Binder content distribution among granule sizes has been discussed as well.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:692890
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Environmental chemistry and green technologies
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-06-23 12:05:53