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undergraduate thesis
Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:299707
Jambriško, Donata
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Jambriško, D. (2018). Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:299707

Jambriško, Donata. "Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:299707

Jambriško, Donata. "Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:299707

Jambriško, D. (2018). 'Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:299707

Jambriško D. Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:299707

D. Jambriško, "Priprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:299707

Metadata
TitlePriprava novih derivata 2-aminobenzimidazola kao potencijalnih biološki aktivnih spojeva
Title (english)Synthesis of novel 2-aminobenzimidazole derivatives as potential biologically active compounds
AuthorDonata Jambriško
MentorMarijana Hranjec (mentor)
Committee memberMarijana Hranjec (predsjednik povjerenstva)
Committee memberMaja Cindrić (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-09-05, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
U okviru ovog rada provedena je sinteza novih metoksi derivata Nmetilbenzimidazolil supstituiranih benzamida 17-19 i njihovih cijano derivata 20-22. Ciljani spojevi priređeni su klasičnim reakcijama organske sinteze. Sinteza prekursora 2-amino-5-cijano-1-metilbenzimidazola 10 potpomognuta je mikrovalovima polazeći od 4-klor-3-nitrobenzonitrila 7. Kondenzacijom odgovarajućih supstituiranih benzoil-klorida 14, 15 i 16 s odgovarajućim 2-amino-N-metilbenzimidazolom 6, odnosno 10 priređeni su metoksi supstituirani benzamidi 19-22. Strukture priređenih trimetoksiderivata 19 i 22 potvrđene su 1H NMR i 13C NMR spektroskopijom. Nastanak metoksi 17, 20 i dimetoksi 18, 21 derivata potvrđen je masenom spektrometrijom, no izoliranje istih nije bilo uspješno.
Abstract (english)
In this work, the synthesis of novel methoxy N-methylbenzimidazolyl substituted benzamides 17-19 and their cyano derivatives 20-22 has been carried out. Targeted compounds were prepared by classic organic synthesis reactions. Synthesis of the main precursor, namely 2-amino-5-cyano-1-methylbenzimidazole 10 was endorsed by microwaves starting from 4-chloro-3-nitrobenzonitrile 7. The condensation of the corresponding substituted benzoyl-chlorides 14, 15 and 16 with 2-amino-N-methylbenzimidazole 6 or 2- amino-5-cyano-1-methylbenzimidazole 10 gave methoxy-substituted benzamides 19-22. The structures of the trimethoxy substituted derivatives 19 and 22 were confirmed by means of 1H NMR and 13C NMR spectroscopy. Despite the emergence of methoxy 17, 20 and dimethoxy 18, 21 derivatives was confirmed by mass spectrometry, the isolation of listed compounds has not been successful.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:299707
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2021-06-24 10:30:03