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undergraduate thesis
Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:407725
Ondrušek, Magdalena
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Ondrušek, M. (2018). Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:407725

Ondrušek, Magdalena. "Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:407725

Ondrušek, Magdalena. "Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:407725

Ondrušek, M. (2018). 'Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:407725

Ondrušek M. Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:149:407725

M. Ondrušek, "Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:407725

Metadata
TitleOdređivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom
Title (english)Determination of dissociation constants of selected pharmaceuticals using spectrophotometric
AuthorMagdalena Ondrušek
MentorSandra Babić (mentor)
Committee memberSandra Babić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberMartina Biošić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-09-06, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
U ovom radu određene su konstante disocijacije (KK) šest farmaceutika (nitrofurantoin, sulfametazin, hidroksiklorokin, cefdinir, metoklopramid i trimetoprim) spektrofotometrijskom metodom. Korišteni su puferi ionske jakosti 0,1 mol/L s rasponom pH-vrijednosti od 3,45 – 10,11. Spektofotometrijskom analizom dobivene su ovisnosti apsorbancije o pH-vrijednosti za svaki farmaceutik iz kojih je određena pKK vrijednost pronalaženjem točke infleksije. Rezultati pokazuju da svi ispitivani farmaceutici imaju jednu konstantu disocijacije čije su pKK-vrijednosti između 7 i 10. Dobivene vrijednosti konstanti uspoređene su s literaturnim podacima. Određene konstante disocijacije farmaceutika omogućiti će bolje razumijevanje ponašanja farmaceutika u okolišu i brži razvoj metoda njihova određivanja.
Abstract (english)
In this work the acid dissociation constants (Ka) of six pharmaceuticals (nitrofurantoine, sulfamethazine, hydroxychloroquine, cefdinir, metoclopramide and trimethoprim) were determined by spectrophotometric method. The pH of the buffers was in the range 3.45 – 10.11 pH units, with ionic strength of 0.1 mol/L. Based on the results of spectrophotometric measurement, correlation between absorbance and pH was determined for each pharmaceutical. The pKa value was determined by finding inflection point. Results indicate that the pKa values for all pharmaceuticals are approximately between 7 and 10. In addition, the values obtained in this work are compared with the pKa’s available in literature determined by various techniques. These results are expected to facilitate the understanding on occurrence, fate and effects of pharmaceuticals in the environment and analytical methods development.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:407725
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
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Created on2021-06-24 10:59:52