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master's thesis
3D-tiskani oralni dozirni oblici dronedaron-hidroklorida
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:794702
Kezerić, Kristina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Kezerić, K. (2019). 3D-tiskani oralni dozirni oblici dronedaron-hidroklorida (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:794702

Kezerić, Kristina. "3D-tiskani oralni dozirni oblici dronedaron-hidroklorida." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:794702

Kezerić, Kristina. "3D-tiskani oralni dozirni oblici dronedaron-hidroklorida." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:794702

Kezerić, K. (2019). '3D-tiskani oralni dozirni oblici dronedaron-hidroklorida', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:794702

Kezerić K. 3D-tiskani oralni dozirni oblici dronedaron-hidroklorida [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:794702

K. Kezerić, "3D-tiskani oralni dozirni oblici dronedaron-hidroklorida", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:794702

Metadata
Title3D-tiskani oralni dozirni oblici dronedaron-hidroklorida
Title (english)3D printed oral dosage forms containing dronedarone hydrochloride
AuthorKristina Kezerić
MentorGordana Matijašić (mentor)
Committee memberGordana Matijašić (predsjednik povjerenstva)
Committee memberDomagoj Vrsaljko (član povjerenstva)
Committee memberAna Vrsalović Presečki (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Tehnologija 3D-tiskanja u zadnje se vrijeme sve češće primjenjuje u farmaceutskoj industriji. Do sada je proizveden niz formulacija, uključujući one koje sadrže više djelatnih tvari, različite geometrije i karakteristika oslobađanja, a sve u svrhu okretanja prema konceptu personalizirane medicine. Cilj ovog istraživanja bio je ispitati mogućnost primjene aditivne proizvodnje za izradu tableta različitih gustoća ispune koje sadrže djelatnu tvar dronedaron-hidroklorid. Praćene su promjene koje se događaju od inicijalnog materijala, preko filamenta do konačne tablete te utjecaj gustoće ispune tablete na kinetiku oslobađanja dronedarona. Za proizvodnju filamenta pripravljene su dvije različite mješavine koje su sadržavale jednak udio dronedaron-hidroklorida, komercijalnog PVA-filamenta i aditiva (poli(etilen-glikol) / sorbitol) te je provedena termogravimetrijska analiza DNR-a. Filamenti su pripravljeni ekstrudiranjem taljenjem pri 170 °C te im je izmjeren promjer i određen sadržaj DNR-a. Dobiveni filamenti korišteni su za 3D-tiskanje tableta različitih gustoća ispune, postupkom taložnog srašćivanja. Provedeno je ispitivanje in vitro oslobađanja dronedarona iz dobivenih tableta te je određen njegov udio u tabletama. Rezultati ukazuju na to da filament pripravljen iz mješavine koja je sadržavala PEG kao aditiv ima manja odstupanja od ciljanog promjera filamenta (1,75 mm) i ciljanog udjela DNR-a (10 %) od filamenta pripravljenog iz mješavine koja je sadržavala sorbitol kao aditiv, te da ima pravilnu strukturu. Tablete tiskane iz prethodno navedenog filamenta također pokazuju najmanja odstupanja od ciljanog udjela DNR-a te kompaktnu strukturu koja doprinosi ujednačenom in vitro oslobađanju djelatne tvari tijekom 28 sati. Iz navedenog se može zaključiti da je mješavina koja sadrži PEG pogodnija za proces ekstrudiranja te 3D-tiskanje tableta. Ispitivanjima je također dokazano da gustoća ispune tablete utječe na kinetiku oslobađanja DNR-a čime je postignuto da se iz jednog filamenta, s istim sadržajem DNR-a, mogu dobiti tablete različitih doza.
Abstract (english)
Technology of 3D printing is nowadays widely applied in pharmaceutical industry. A great number of formulations, including those containing multiple drugs, different geometry and release characteristics, have already been made. With them, the concept of personalized medicine is introduced. The aim of this research was to produce tablets that contain dronedarone hydrochloride (DNR), with different tablet infill using additive manufacturing. Transitions that take place from initial material to filaments and finally tablets and the effect of tablet infill on release kinetics of drug have been examined. Two different blends containing dronedarone hydrochloride (DNR), polyvinyl alcohol filament and additives polyethylene glycol or sorbitol, were made. Thermogravimetric analysis of DNR was conducted. Filaments were produced by hot melt extrusion at 170 °C, their diameter was measured and the content of DNR was determined. Fused deposition modeling was used for 3D printing of tablets with different material infill from the obtained filaments. Release profiles of DNR from manufactured tablets were obtained using in vitro tests. Content of DNR in tablets was also determined. The results indicate that the filament made out of the blend that contains PEG had smooth surface, slighter deviation from the target filament diameter (1,75 mm) and from the expected DNR content (10%) than the filament containing sorbitol. The tablets made from PEG-containing filament also had the slightest deviation of expected DNR content and a compact structure that contributes to uniform release of DNR during 28 hours. This indicates that the blend that contains PEG is more suitable for extrusion process and 3D printing of tablets. It was proved that material infill has influence on release kinetic of DNR and that different tablet infill can be used to provide different doses from single filament.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:794702
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-02-21 15:17:48