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master's thesis
Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:472736
Milčić, Ela
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Milčić, E. (2019). Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:472736

Milčić, Ela. "Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:472736

Milčić, Ela. "Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:472736

Milčić, E. (2019). 'Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:472736

Milčić E. Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:472736

E. Milčić, "Dinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:472736

Metadata
TitleDinamičko mehanička svojstva PCL/fibroin svile elektroispredenih nosača za regeneraciju oka
Title (english)Dynamic mechanical properties of PCL/silk fibroin elektrospinning scaffolds for eye regeneration
AuthorEla Milčić
MentorEmi Govorčin Bajsić (mentor)
Committee memberEmi Govorčin Bajsić (predsjednik povjerenstva)
Committee memberZlata Hrnjak-Murgić (član povjerenstva)
Committee memberVeljko Filipan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Brojna istraživanja te nova saznanja o materijalima i njihovoj biokompatibilnosti s tkivima potaknula su razvoj tkivnog inženjerstva, što je posljedično dovelo do napretka u regenerativnoj medicini i liječenju pacijenata. Svrha tkivnog inženjerstva je obnova građe i funkcije oštećenih i bolesnih tkiva te olakšanje procesa liječenja za pacijente. Biomaterijali koji se pritom koriste trebaju biti biokompatibilni, biorazgradljivi i netoksični. Fibroin svile je materijal koji se dugi niz godina koristi u biomedicini i pokazuje brojna pozitivna svojstva kao što su dobra mehanička svojstva, biokompatibilnost i biorazgradljivost. Cilj ovog rada je priprema elektroispredenih nosača na osnovi polikaprolaktona (PCL) i različitih udjela fibroina svile (FS) postupkom elektroispredanja. Ispitan je utjecaj FS na strukturu, dinamičko-mehanička svojstva te toplinska svojstva elektroispredenih nosača pomoću infracrvene spektroskopije (FTIR-ATR), dinamičko mehaničke analize (DMA) i termogravimetrijske analize (TGA). Uzorci su podvrgnuti i određivanju mehaničkih svojstava pomoću kidalice. Dobiveni rezultati DMA analize pokazuju da porastom udjela FS dolazi do smanjenja vrijednosti modula gubitka, E'' te povećanja vrijednosti staklišta, Tg. Toplinska stabilnost elektroispredenih nosača određena TGA analizom smanjuje se porastom udjela FS. Dobiveni FTIR spektri pokazuju da je FS uspješno ugrađen u elektroispredeni PCL vlaknasti nosač. Mjerenje mehaničkih svojstava pokazuje da se prekidna čvrstoća smanjuje porastom udjela FS u elektroispredenim nosačima.
Abstract (english)
Many investigations and new findings about materials and their compatibility with tissues have initiated tissue engineering growth. Consequently, that led to progress in regenerative medicine and patients recovery. Main purpose of tissue engineering is to restore damaged and diseased tissues and to ease a healing process for patients. Biomaterials used in tissue engineering should be biocompatible, biodegradable and non-toxic. Silk fibroin is a material that has been used in biomedicine for many years and it shows many positive properties such as mechanical properties, biocompatibility and biodegradability. The aim of this work is to prepare electrospun scaffolds based on polycaprolactone (PCL) and different silk fibroin (SF) content by electrospinning. The effect of SF on the structure, dynamicmechanical properties and thermal properties of electrospun scaffolds were investigated by infrared spectroscopy (FTIR-ATR), dynamic-mechanical analysis (DMA) and thermogravimetric analysis (TGA). The mechanical properties were also determined using a testing machine. Results obtained with DMA showed that with addition of silk fibroin, the loss modulus, E'' decreases and the glass transition temperature, Tg increases. Thermal stability of electrospun scaffolds determined by TGA decreases with the addition of silk fibroin. The FTIR results showed that the silk fibroin was successfully introduced to PCL scaffolds. Mechanical properties showed that the tensile strength decreases with increasing SF content in electrospun scaffolds.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:472736
ProjectNumber: IP-2016-06-6878
Title: Ciljana izrada prototipa vlaknastog nosača za uzgoj tkivnih stanica kombiniranim elektroispredanjem
Acronym: COMBOELECTROSPUN
Leader: Budimir Mijović
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Materials Science and Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2022-02-26 10:10:41