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master's thesis
Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:388311
Pavišić, Marijana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Pavišić, M. (2019). Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:388311

Pavišić, Marijana. "Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:388311

Pavišić, Marijana. "Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:388311

Pavišić, M. (2019). 'Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:388311

Pavišić M. Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:388311

M. Pavišić, "Karakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:388311

Metadata
TitleKarakterizacija polimorfnih formi odabrane aktivne farmaceutske supstance
Title (english)Characterization of polymorphic forms of selected active pharmaceutical substance
AuthorMarijana Pavišić
MentorŠime Ukić (mentor)
Committee memberŠime Ukić (predsjednik povjerenstva)
Committee memberLidija Furač (član povjerenstva)
Committee memberSanja Matečić Mušanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U sklopu ovog rada prikazane su metode fizikalne karakterizacije i pretraživanja polimorfnih formi aktivne farmaceutske supstance (eng. Active Pharamaceutical Ingredient) te određena stabilnost, higroskopna i morfološka svojstva. Zbog politike tvrtke Pliva Hrvatska d.o.o., kroz rad se ne navodi točan naziv aktivne farmaceutske supstance, već se koristi skraćenica API. Za potrebe fizikalne karakterizacije API-ja primijenjene su rendgenska difrakcijska analiza, diferencijalna pretražna kalorimetrija i termogravimetrijska analiza. Higroskopna svojstva API-ja praćena su njegovim izlaganjem uvjetima relativne vlažnosti na 25 °C te primjenom metode dinamičke sorpcije vlage, dok su za praćenje morfoloških svojstava primijenjene optička mikroskopija i skenirajuća elektronska mikroskopija. Pretraživanje polimorfnih formi ispitivanog API-ja provedeno je njegovim izlaganjem parama otapala kao i izlaganjem otapalima u suspenziji. Također, praćena je i polimorfna stabilnost API-ja tijekom izlaganja različitim stresnim testovima: povišenim temperaturama, povišenim tlačnim silama, mljevenju u kugličnom mlinu i u tarioniku. Fizikalnom karakterizacijom polazne API forme utvrđeno je da je ona stabilna tijekom izlaganja uvjetima relativne vlažnost na sobnoj temperaturi te prilikom izlaganja mehaničkom djelovanju poput tlačnih sila, mljevenja u tarioniku i mehaničkom mlinu. Pretraživanje polimorfnih formi API-ja, provedeno izlaganjem polazne API forme različitim otapalima, rezultiralo je dobivanjem tri nove solvatne forme: 2-metil THF solvata, p-ksilen solvata te n-butanol solvata.
Abstract (english)
This work presents the methods of physical characterization and search of Active Pharmaceutical Ingredient and its polymorphs and determination of its stability, hygroscopic and morphological properties. The exact name of the Active Pharmaceutical Ingredient is not mentioned in the work, due to the policy of Pliva Hrvatska d.o.o.; instead abbreviation API is used. X-Ray diffraction analysis, differential scanning calorimetry and thermogravimetric analysis were applied for physical characterization of the API. The API's hygroscopic properties were monitored by exposing the sample to relative humidity conditions at room temperature and by using the dynamic vapor sorption method. Morphological properties were determined by optical microscopy and scanning electron microscopy. Screening for polymorphic forms of the API was performed by exposing API to solvent's vapor and solvent in suspensions. Also, polymorphic stability of the API was monitored while exposed to various stress tests: exposure to high temperatures and high pressure, milling in ball mill and mortar. Physical characterization of the initial API form indicated its stability during the exposure to relative humidity at room temperature and mechanical actions such as high pressure, milling in mortar and ball mill. Three solvated forms were obtained as a result of the screening process: 2-methyl THF solvate, p-xylene solvate and n-butanol solvate.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:388311
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-02-26 20:11:00