Introduction and research objectives: Knee injuries are a major health problem with various causes and types, including acute ligament injuries, meniscus damage and chronic conditions such as tendinitis. The aim of this study is to investigate the incidence and characteristics of knee injuries in patients of the Specialized Orthopedic Hospital Biograd na Moru in the period from 2021 to 2023. The specific objectives include analyzing the frequency, distribution by gender, length of hospital stay, treatment methods and recovery time depending on the type of injury. Materials and methods: The research was conducted through a retrospective review of medical records of patients over 18 years of age with knee injuries at the Specialized Orthopedic Hospital Biograd na Moru in the period 2021-2023. Data were collected and analyzed using standardized procedures to ensure accuracy, and statistical analysis included methods such as the Mann-Whitney U test and the Kruskal-Wallis test. The study was conducted ethically, with ethics committee approval, and data anonymization and patient privacy were ensured. Results: The study involved 1142 patients with knee injuries, 43.5 % of whom were men and 56.5 % women, most of whom were over 50 years old. The most common diagnosis was M17 (88.6 %), and 97.1 % of patients underwent surgery, with an average hospital stay of 7.37 days. Statistically significant differences in the distribution of diagnoses by gender, age and hospitalization days indicate different injury and treatment patterns in the different patient groups. Conclusion: The study found that knee osteoarthritis (M17) is the most common diagnosis and is more common in older adults and women, while dislocations and sprains are more common in men. Patients with serious injuries such as fractures need to stay in hospital longer and are more likely to undergo surgery. Statistically significant differences in the duration of hospitalization between the sexes point to the need for tailored concepts for the treatment and prevention of knee injuries.