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master's thesis
ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA
Rijeka: University of Rijeka, Faculty of Health Studies, 2020. urn:nbn:hr:184:610875
Biškup, Klara
University of Rijeka
Faculty of Health Studies
Department of Basic Medical Sciences

Institutional repository: Repository of the University of Rijeka, Faculty of Health Studies

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Biškup, K. (2020). ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA (Master's thesis). Rijeka: University of Rijeka, Faculty of Health Studies. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:610875

Biškup, Klara. "ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA." Master's thesis, University of Rijeka, Faculty of Health Studies, 2020. https://urn.nsk.hr/urn:nbn:hr:184:610875

Biškup, Klara. "ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA." Master's thesis, University of Rijeka, Faculty of Health Studies, 2020. https://urn.nsk.hr/urn:nbn:hr:184:610875

Biškup, K. (2020). 'ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA', Master's thesis, University of Rijeka, Faculty of Health Studies, accessed 24 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:610875

Biškup K. ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA [Master's thesis]. Rijeka: University of Rijeka, Faculty of Health Studies; 2020 [cited 2024 December 24] Available at: https://urn.nsk.hr/urn:nbn:hr:184:610875

K. Biškup, "ULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA", Master's thesis, University of Rijeka, Faculty of Health Studies, Rijeka, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:184:610875

Metadata
TitleULOGA RAB PROTEINA U INFEKCIJI ADENOVIRUSA
Title (english)ROLE OF RAB PROTEINS IN ADENOVIRUS INFECTION
AuthorKlara Biškup
MentorSandra Kraljević Pavelić (mentor)
Committee memberKsenija Božinović (predsjednik povjerenstva)
Committee memberMladenka Malenica (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Health Studies
(Department of Basic Medical Sciences)
Rijeka
Defense date and country2020-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract
Adenovirusi su DNA virusi i pripadaju obitelji Adenoviridae, rodu Mastadenovirus a njihova su molekularna i biološka svojstva dobro poznata. Također radi se o virusima čijim se genomom lako manipulira, a mogu se koristiti i za uspješan unos virusnog genoma u stanicu domaćina, zbog čega su to dobri vektori za prijenos gena u svrhu genske terapije i vakcinacije. Da bi infekcija adenovirusa bila uspješna, potrebni su različiti stanični proteini, koje adenovirus koristi kako bi uspješno dostavio svoj genom u jezgru stanice domaćina i osigurao ekspresiju vlastitih gena. U tu grupu proteina koji su važni u procesu infekcije spadaju i Rab proteini koji čine najveću obitelj malih enzima GTPaza i kontroliraju različite korake unutarstaničnog transporta. Za uspješnu infekciju adenovirusa najvažniji su Rab proteini Rab5, Rab7, Rab9 i Rab11. Upravo je razumijevanje dinamike Rab proteina i njihove uključenosti u unutarstanični transport, važno za rasvjetljavanje mehanizma adenovirusne infekcije, endocitoze kao procesa te razvijanje novih strategija u pristupu liječenja raznih bolesti nastalih poremećajem funkcije Rab proteina. Ovaj diplomski rad stoga daje detaljni teorijski pregled o ulozi Rab proteina u infekciji stanica čovjeka adenovirusom.
Abstract (english)
Adenoviruses are DNA viruses that belong to the Adenoviridae family, genus Mastadenovirus and their molecular biology is well-known. They are also viruses whose genome is easly manipulated, and can very successful introduct the viral genome into the host cell, which has shown why they are recognized as an excellent candidates for gene therapy and vaccination purposes. In order to maintain efficient infection, adenoviruses use different cellular proteins to successfully deliver genome into the cell nucleus and ensure the expression of its own genes. One of the most important proteins involved in adenovirus infection are Rab proteins, which make largest family of small GTPases and control the various steps of intracellular transport. Understanding the dynamics of Rab proteins and their involvement in intracellular transport, allows better understanding of the adenoviral infection mechanism, endocytosis as a process and development of new strategies in the treatment of various diseases caused by Rab protein dysfunction. This thesis consists of detailed theoretical overview of the Rab protein role in human adenovirus cell infection, specifically Rab5, Rab7, Rab9 and Rab11.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:610875
Study programmeTitle: Graduate university Study of Clinical Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kliničkog nutricionizma (magistar/magistra kliničkog nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-11-09 10:18:28