The global issue of premature deterioration in bridges and other structures requires a switch from prescriptive to performance-based durability design of infrastructure, taking into account specific environmental exposure and a combination of actions to which a structure will be exposed during its service life. Although many numerical models for service life prediction have been developed in the last four decades, their application on real structures is still not on a satisfactory level. This is due to the complexity of mechanical, physical, thermal and chemical processes related to the deterioration processes, but also due to difficulty in quantifying the material, structural, environmental and climate performance indicators and their interactions. In addition, there are several sources of uncertainty and spatial variability related to deterioration processes, exposure, models, inspection, etc. These uncertainties and spatial variability affect service life predictions and should be quantified and considered in a comprehensive form. This Research Topic deals with the new advances reached in the last years in the field of service life prediction (deterministic or probabilistic) of bridges and different type of infrastructure, including the following topics: (I) Service life prediction models for determining the time to repair, (ii) Life cycle and service life assessment models of concrete, steel and wooden structures, (iii) Impact of hurricane hazard and climate change on service life prediction, (iv) Case studies, (v) New methods for structure durability testing in laboratory and on site, (vi) Durability of ultra-high-performance concrete structures, (vii) Service life design in the framework of accelerated bridge construction, (viii) Optimization of performance-based maintenance plan.