The aim of this paper is to analyse sewage sludge production at the level of Medimurje and Varazdin counties with economic analysis of acceptable technical/technological solutions for sludge management routes. The topic is very broad, so the focus was placed on four variants of sludge disposal, which were determined by preliminary analysis to be the most applicable for the area in question. These are: 1) disposal of sewage sludge in agriculture, 2) incineration of sludge in a central mono-incinerator, 3) composting for the area of Varazdin County and at the same time use of sludge reed beds for the area of Medimurje County, and 4) export of sludge outside the state borders. Based on the analysis carried out for the described four variants, sludge incineration in a regional mono-incinerator turned out as the economically most advantageous solution, while the variant that includes disposal of sludge in agriculture has showed as the most expensive one. The last one also showed the largest range of costs uncertainties, but the mentioned facts are greatly influenced by unfavourable legislation, the changes of which in a more rational direction would greatly contribute to the greater competitiveness of this variant. Overall, taking into account the lowest cost and uncertainties in the predicted unit costs, the sludge composting in the Varazdin County and the construction of a reed beds for the Medimurje County, turned out to be the optimal variant. This solution is also the one that was ultimately adopted in practice.