The aim of the research study was to examine the relationship between value orientation, religiosity, search for meaning and consumption of marijuana in adolescents. A total of 249 participants of three high schools in Dubrovnik - Gymnasium, Economics School and Maritime-Technical School (Nm = 150, NZ = 99) participated in the study. The participants completed the Scale of Value Orientation (Franc, Šakić and Ivičić, 2002), The Santa Clara Strenght of Religious Faith Questionnaire (Plante and Boccaccini, 1997), the Meaning of Life Questionnaire (Steger and Shin, 2010) and Marijuana Questionnaire and responded to a list of questions about their demographic characteristics. The data was collected during teaching lessons with in the presence of teachers or psychologists. Most adolescents do not consume marijuana (68.7%), and young men and girls do not differ in marijuana consumption. Furthermore, girls are more represented by self-existent and conventional values while younger men are more likely to be presently searching for meaning. It has also been shown that marijuana consumption is statistically significantly negatively linked to the conventional values and the strenght of religious faith, so that adolescents with a lower presence of conventional values and stronger religious faith are more likely to consume marijuana. In addition, only the girls were associated with marijuana consumption, conventional and elfdefeating values, and religiosity. Despite expectations that value orientation, religiosity, and search for meaning will contribute to explaining the use of marijuana, they have not been confirmed.