The emergence of the COVID-19 pandemic at the beginning of 2020 led to major changes that drastically changed lives of people around the world in the following years. Freedom of movement and socialization were strictly limited to reduce the risk of further spread of the virus. The pandemic didn't bypass the business world either, and companies had to make quick decisions at a given moment to protect their business, as well as their employees. Many companies followed the recommendations of the governing bodies and instructed their employees to work from home. However, decision-makers in other companies adapted the way their employees work to specific business or their own attitudes. The goal of this research was to gain insight into the work-family conflict, work and general life satisfaction of employees who differed in the way they worked during the COVID-19 pandemic. 466 employed persons from the territory of the Republic of Croatia participated in the research. The quantitative part of the data was collected online by students in the Psychology of Organizational Behavior course at the Faculty of Croatian Studies in the period from November 2020 to February 2021. The results obtained by multivariate analysis of variance showed the existence of a statistically significant difference between employees who worked from home and hybridly and those who worked from the office in satisfaction with work and general life, in such a way that employees who worked from home and hybridly reported greater job and general life satisfaction. The quantitative part of the research was complemented with 14 qualitative interviews conducted in November 2022, where researchers obtained better insight into the emotional state, way of thinking and behavior of the employees of each group.