In this paper, we explore human's possible internal inclination towards the transcendent and analyze three significant dimensions: neuroscientific, evolutionary psychological, and cultural. Firstly, we investigate how science and religion are often perceived as rivals but acknowledge the potential for their collaboration. Furthermore, we analyze different conceptions of the soul and explore its location according to various scientific and philosophical interpretations. Next, we analyze the field of neuroscience, including phrenology as a precursor to modern neuroscience, and the connection between the self and religious experiences within the human brain's neurology and neurochemistry. We touch upon the differences between the ordinary mind and individuals with neurological disorders in their perception of self. In the next chapter we analyze the relationship between evolution and religion. We inquire whether humans have an innate predisposition towards the concept of transcendence; we examine how children perceive theistic concepts and the notion of life after death. Additionally, we analyze evolutionary factors that shape religious experiences, including dreams, language, reason, and imagination. In the realm of culture, we examine the process of cultural learning and the transmission of religion, as well as the impact of religion on society. We study gods as social beings, various aspects of religious rituals, and religious language. We also delve into the culture of disbelief - atheism. Throughout these chapters, we investigate the intricate relationship between science, religion, and culture and how they shape our understanding of the self and its tendency for transcendence. We conclude that this relationship is complex and that science and religion can be partners in comprehending human existence and its inclination towards the transcendent. Moreover, the inclination towards the transcendent can only be explained as a combination of various biological innate factors and cultural learned factors.