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Scientific paper - Original scientific paper
Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study
BMC Cardiovascular Disorders, 17 (2017), 1; 2-9. https://doi.org/10.1186/s12872-017-0721-0
Boban, Marko; Peša, Vladimir; Gabrić, Ivo Darko; Manola, Šime; Peršić, Viktor; Antić-Kauzlarić, Helena; Žulj, Marinko; Včev, Aleksandar

Institutional repository: Repository UHC Osijek

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Boban, M., Peša, V., Gabrić, I. D., Manola, Š., Peršić, V., Antić Kauzlarić, H. ... Včev, A. (2017). Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study. BMC Cardiovascular Disorders, 17. (1), 2-9. doi: 10.1186/s12872-017-0721-0

Boban, Marko, et al. "Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study." BMC Cardiovascular Disorders, vol. 17, no. 1, 2017, pp. 2-9. https://doi.org/10.1186/s12872-017-0721-0

Boban, Marko, Vladimir Peša, Ivo Darko Gabrić, Šime Manola, Viktor Peršić, Helena Antić Kauzlarić, Marinko Žulj and Aleksandar Včev. "Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study." BMC Cardiovascular Disorders 17, no. 1 (2017): 2-9. https://doi.org/10.1186/s12872-017-0721-0

Boban, M., et al. (2017) 'Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study', BMC Cardiovascular Disorders, 17(1), pp. 2-9. doi: 10.1186/s12872-017-0721-0

Boban M, Peša V, Gabrić ID, Manola Š, Peršić V, Antić Kauzlarić H, and sur.. Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study. BMC Cardiovascular Disorders [Internet]. 2017 [cited 2024 November 22];17(1):2-9. doi: 10.1186/s12872-017-0721-0

M. Boban, et al., "Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study", BMC Cardiovascular Disorders, vol. 17, no. 1, pp. 2-9, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:159247. [Accessed: 22 November 2024]

Metadata
Title (english)Auxiliary Diagnostic Potential of Ventricle Geometry and late Gadolinium Enhancement in left Ventricular Non-compaction; Non-randomized case Control Study
AuthorMarko Boban
MBZ: 340711
AuthorVladimir Peša
AuthorIvo Darko Gabrić
MBZ: 352036
AuthorŠime Manola
MBZ: 284123
AuthorViktor Peršić
MBZ: 303361
AuthorHelena Antić-Kauzlarić
AuthorMarinko Žulj
AuthorAleksandar Včev
MBZ: 141721
Author's institutionUniversity of Rijeka
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls. Methods: Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital’s database (3.75 years; n=1975 exams). Matching sample of controls included cases with no structural heart disease, hypertrophic or dilative cardiomyopathy, arrhythmogenic right ventricular dysplasia or subacute myocarditis. Eccentricity of the left ventricle was measured at end diastole in the region with pronounced NC and maximal to minimal ratio (MaxMinEDDR) was calculated. Results: Study included 255 patients referred for CMR, 100 (39.2%) with LVNC (prevalence in the studied period 5.01%) and 155 (60.8%) controls. Existing LGE had sensitivity of 52.5% (95%-CI:42.3–62.5), specificity of 80.4% (95%-CI:73.2–86.5) for LVNC, area under curve (AUC) 0.664 (95%-CI:0.603–0.722);p<0.001. MaxMinEDDR>1.10 had sensitivity of 95.0% (95%- CI:88.7–98.4), specificity of 82.6% (95%-CI: 75.7–88.2) for LVNC, AUC 0.917 (95%-CI:0.876–0.948); p<0.001. LGE correlated with Max-Min-EDD-R (Rho=0.130; p=0.038) and there was significant difference in ROC analysis ΔAUC0.244 (95%-CI:0. 175–0.314); p<0.001. LGE also correlated negatively with stroke volume and systolic function (both p<0.05, respectively). Conclusions: LGE was found to be frequently expressed in patients with LVNC, but without sufficient power to be used as a discriminative diagnostic parameter. Both LGE and eccentricity of the left ventricle were found to be relatively solid diagnostic landmarks of complex infrastructural and functional changes within the failing heart.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBMC Cardiovascular Disorders
Numberingvol. 17, no. 1, pp. 2-9
e-ISSN1471-2261
DOIhttps://doi.org/10.1186/s12872-017-0721-0
URN:NBNurn:nbn:hr:239:159247
Publication2017
Document URLhttps://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-017-0721-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-10-23 11:00:36