prikaz prve stranice dokumenta Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy
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Scientific paper - Original scientific paper
Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy
Medical Science Monitor, 24 (2018); 1880-1886. https://doi.org/10.12659/MSM.906111
Boban, Marko; Peša, Vladimir; Kauzlarić-Antić, Helena; Brusich, Sandro; Rotim, Ante; Madžar, Tomislav; Žulj, Marko; Včev, Aleksandar

Institutional repository: Repository UHC Osijek

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Boban, M., Peša, V., Kauzlarić Antić, H., Brusich, S., Rotim, A., Madžar, T. ... Včev, A. (2018). Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy. Medical Science Monitor, 24., 1880-1886. doi: 10.12659/MSM.906111

Boban, Marko, et al. "Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy." Medical Science Monitor, vol. 24, 2018, pp. 1880-1886. https://doi.org/10.12659/MSM.906111

Boban, Marko, Vladimir Peša, Helena Kauzlarić Antić, Sandro Brusich, Ante Rotim, Tomislav Madžar, Marko Žulj and Aleksandar Včev. "Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy." Medical Science Monitor 24 (2018): 1880-1886. https://doi.org/10.12659/MSM.906111

Boban, M., et al. (2018) 'Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy', Medical Science Monitor, 24, pp. 1880-1886. doi: 10.12659/MSM.906111

Boban M, Peša V, Kauzlarić Antić H, Brusich S, Rotim A, Madžar T, and sur.. Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy. Medical Science Monitor [Internet]. 2018 [cited 2024 November 27];24:1880-1886. doi: 10.12659/MSM.906111

M. Boban, et al., "Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy", Medical Science Monitor, vol. 24, pp. 1880-1886, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:980426. [Accessed: 27 November 2024]

Metadata
Title (english)Ventricular Diastolic Dimension over Maximal Myocardial Thickness is Robust Landmark of Systolic Impairment in Patients with Hypertrophic Cardiomyopathy
AuthorMarko Boban
MBZ: 340711
AuthorVladimir Peša
AuthorHelena Kauzlarić-Antić
AuthorSandro Brusich
MBZ: 282461
AuthorAnte Rotim
AuthorTomislav Madžar
MBZ: 283982
AuthorMarko Žulj
AuthorAleksandar Včev
MBZ: 141721
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: The effects of focal hypertrophy on geometry of the left ventricle and systolic function have not been studied in patients with hypertrophic cardiomyopathy (HCM), despite the fact that the former is the most prominent disease characteristic. The aim of our study was to analyze systolic function over ventricle geometry, generating a functional index made from left ventricle end diastolic dimension (LVEDD) divided by end diastolic thickness of the region with maximal extent of hypertrophy and interventricular septum. Material/Methods: Our hospital database of cardiac magnetic resonance was screened for HCM. Geometric functional index (GFI) was calculated for LVEDD over maximal end diastolic thickness (MaxEDT) giving GFI-M, while LVEDD over interventricular septum was expressed as GFI-I. There were 55 consecutive patients with HCM. Results: There were 43 males (78.2%) and 12 females (21.8%). The mean age was 52.3±16.7 years (range: 15.5–76.4 years). A significant difference of GFI was found for preserved versus impaired systolic function of the left ventricle (preserved systolic function); GFI-M 2.28±0.60 versus 3.66±0.50 (p<0.001), and GFI-I 2.75±0.88 versus 3.81±0.87 (p<0.001), respectively. Diagnostic value was tested using receiver operating curve (ROC) analyzes, with GFI-M area under curve (AUC)=0.959 (95% CI: 0.868–0.994); (p<0.001) and GFI-I-AUC=0.847 (0.724–0.930); (p<0.001). GFI-M was superior to GFI-I for appraisal of left ventricle systolic dysfunction in HCM; DAUC=0.112 (0.018–0.207); (p=0.020). Conclusions: GFI is a simple tool, with high sensitivity and specificity for detecting impairment of systolic function in patients with HCM. Further studies would be necessary to investigate its clinical and prognostic impacts, as well as reproducibility with prospective validation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Science Monitor
Numberingvol. 24, pp. 1880-1886
p-ISSN1234-1010
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.906111
URN:NBNurn:nbn:hr:239:980426
Publication2018
Document URLhttps://www.medscimonit.com/abstract/index/idArt/906111
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-10-23 11:25:32