prikaz prve stranice dokumenta Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids
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Scientific paper - Original scientific paper
Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids
Diabetes and Vascular Disease Research, 12 (2015), 1; 33-45. https://doi.org/10.1177/1479164114553424
Kibel, Aleksandar; Novak, Sanja; ĆosiĆ, Anita; Mihaljević, Zrinka; Falck, John R; Drenjančević, Ines

Institutional repository: Repository UHC Osijek

Cite this document

Kibel, A., Novak, S., ĆosiĆ, A., Mihaljević, Z., Falck, J. R. & Drenjančević, I. (2015). Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids. Diabetes and Vascular Disease Research, 12. (1), 33-45. doi: 10.1177/1479164114553424

Kibel, Aleksandar, et al. "Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids." Diabetes and Vascular Disease Research, vol. 12, no. 1, 2015, pp. 33-45. https://doi.org/10.1177/1479164114553424

Kibel, Aleksandar, Sanja Novak, Anita ĆosiĆ, Zrinka Mihaljević, John R Falck and Ines Drenjančević. "Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids." Diabetes and Vascular Disease Research 12, no. 1 (2015): 33-45. https://doi.org/10.1177/1479164114553424

Kibel, A., et al. (2015) 'Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids', Diabetes and Vascular Disease Research, 12(1), pp. 33-45. doi: 10.1177/1479164114553424

Kibel A, Novak S, ĆosiĆ A, Mihaljević Z, Falck JR, Drenjančević I. Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids. Diabetes and Vascular Disease Research [Internet]. 2015 [cited 2024 November 07];12(1):33-45. doi: 10.1177/1479164114553424

A. Kibel, S. Novak, A. ĆosiĆ, Z. Mihaljević, J. R. Falck and I. Drenjančević, "Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids", Diabetes and Vascular Disease Research, vol. 12, no. 1, pp. 33-45, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:597138. [Accessed: 07 November 2024]

Metadata
Title (english)Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids
AuthorAleksandar Kibel
MBZ: 344370
AuthorSanja Novak
MBZ: 326355
AuthorAnita ĆosiĆ
AuthorZrinka Mihaljević
MBZ: 324952
AuthorJohn R Falck
AuthorInes Drenjančević
MBZ: 209603
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract (english)
Previously, a facilitating effect of hyperbaric oxygenation (HBO₂) on aortic ring responses to angiotensin-(1-7) in healthy rats was reported, with epoxyeicosatrienoic acids (EETs) possibly playing an important role. The aim of this study was to assess whether HBO₂ exerts similar effects in diabetic rats and to further explore the role of specific cytochrome P450 (CYP) enzymes in changes induced by HBO₂. Aortic relaxation to angiotensin-(1-7) was significantly higher in HBO₂ diabetic rats compared to control diabetic rats, while HBO₂ had no effect on angiotensin II contraction. N-methylsulphonyl-6-(2 propargyloxyphenyl /hexanamide inhibited the facilitation of angiotensin-(1-7) responses in HBO₂ rats, suggesting an important role of EETs in this modulation. mRNA expression of CYP2J3 and protein expression of CYP2C11 were significantly upregulated in HBO₂ diabetic rats, whereas CYP4A1, CYP4A2 and CYP4A3 mRNA and CYP2J3 protein expression was similar between groups. Mean arterial pressure, ferric reducing ability of plasma and Thiobarbituric Acid Reactive Substances levels and serum angiotensin-(1-7) concentrations were not significantly changed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiabetes and Vascular Disease Research
Numberingvol. 12, no. 1, pp. 33-45
p-ISSN1479-1641
e-ISSN1752-8984
DOIhttps://doi.org/10.1177/1479164114553424
URN:NBNurn:nbn:hr:239:597138
Publication2015
Document URLhttps://journals.sagepub.com/doi/10.1177/1479164114553424
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2019-10-29 08:10:32