prikaz prve stranice dokumenta The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women
  Download
PDF 425.29 KB
Scientific paper - Original scientific paper
The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women
Journal of Maternal-Fetal and Neonatal Medicine, 29 (2015), 2; 264-269. https://doi.org/10.3109/14767058.2014.998189
Lenz, Bahrija; Samardžija, Marina; Drenjančević, Domagoj; Zibar, Davor; Samardžija, Marko; Milostić-Srb, Andrea

Institutional repository: Repository UHC Osijek

Cite this document

Lenz, B., Samardžija, M., Drenjančević, D., Zibar, D., Samardžija, M. & Milostić Srb, A. (2015). The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women. Journal of Maternal-Fetal and Neonatal Medicine, 29. (2), 264-269. doi: 10.3109/14767058.2014.998189

Lenz, Bahrija, et al. "The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women." Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, no. 2, 2015, pp. 264-269. https://doi.org/10.3109/14767058.2014.998189

Lenz, Bahrija, Marina Samardžija, Domagoj Drenjančević, Davor Zibar, Marko Samardžija and Andrea Milostić Srb. "The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women." Journal of Maternal-Fetal and Neonatal Medicine 29, no. 2 (2015): 264-269. https://doi.org/10.3109/14767058.2014.998189

Lenz, B., et al. (2015) 'The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women', Journal of Maternal-Fetal and Neonatal Medicine, 29(2), pp. 264-269. doi: 10.3109/14767058.2014.998189

Lenz B, Samardžija M, Drenjančević D, Zibar D, Samardžija M, Milostić Srb A. The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women. Journal of Maternal-Fetal and Neonatal Medicine [Internet]. 2015 [cited 2024 May 13];29(2):264-269. doi: 10.3109/14767058.2014.998189

B. Lenz, M. Samardžija, D. Drenjančević, D. Zibar, M. Samardžija and A. Milostić Srb, "The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women", Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, no. 2, pp. 264-269, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:836849. [Accessed: 13 May 2024]

Metadata
Title (english)The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women
AuthorBahrija Lenz
MBZ: 261316
AuthorMarina Samardžija
MBZ: 269264
AuthorDomagoj Drenjančević
MBZ: 297300
AuthorDavor Zibar
AuthorMarko Samardžija
AuthorAndrea Milostić-Srb
MBZ: 239325
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
OBJECTIVES: To investigate the genetic and acquired thrombophilic risk factors in pregnancy-associated complications and venous thromboembolism (VTE) and evaluate the association between particular thrombophilic risk factors and thromboembolic complications. METHODS: In this study, pregnant women with pregnancy complications and VTE (N = 101) were the study group, and the control group were women with normal pregnancy (N = 102). All women underwent testing for factor V Leiden mutation (FVL), mutation of the coagulation factors II (FII20210), methylenetetrahydrofolate reductase (MTHFR), plasminogen activator inhibitor-1, antithrombin III (ATIII), protein C (PC) and protein S, lupus anticoagulant (LAC) antibodies, anticardiolipin antibodies and anti-beta-2-glycoprotein-1. RESULTS: In this study group, mutations of the FVL was 15.8% (16/101), FII20210 5.9% (6/101) and the MTHFR at locus 677 was TT in 19.8% (20/101). Deficiency of ATIII and PC were rare: 3.0% and 1.0%, respectively. LAC were significantly higher in the study group than in the control group: 32.7% versus 3.9%; p < 0.0005. Pregnant women with VTE have been more frequent for FVL (41.7%; p < 0.005), PC deficiency (25.0%; p < 0.005) and LAC (33.3%; p < 0.005). Combination of FVL and MTHFR mutation was related to the risk of recurrent fetal death and habitual abortion. CONCLUSION: The inherited and the acquired thrombophilic risk factors were found to be up to 10 times more common in the study group than in the control group.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Maternal-Fetal and Neonatal Medicine
Numberingvol. 29, no. 2, pp. 264-269
p-ISSN1476-7058
e-ISSN1476-4954
DOIhttps://doi.org/10.3109/14767058.2014.998189
URN:NBNurn:nbn:hr:239:836849
Publication2015
Document URLhttps://www.tandfonline.com/doi/full/10.3109/14767058.2014.998189
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2019-10-29 13:27:22