prikaz prve stranice dokumenta Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia
  Download
PDF 654.76 KB
Scientific paper - Original scientific paper
Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia
Archives of Virology, 160 (2015), 1; 297-304. https://doi.org/10.1007/s00705-014-2283-0
Perić, Magdalena; Bošnjak, Zinka; Šarkanj, Bojan; Barbić, Jerko; Antolović-Požgain, Arlen; Ružman, Nataša; Roksandić-Križan, Ivana; Vuković, Dubravka

Institutional repository: Repository UHC Osijek

Cite this document

Perić, M., Bošnjak, Z., Šarkanj, B., Barbić, J., Antolović Požgain, A., Ružman, N. ... Vuković, D. (2015). Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia. Archives of Virology, 160. (1), 297-304. doi: 10.1007/s00705-014-2283-0

Perić, Magdalena, et al. "Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia." Archives of Virology, vol. 160, no. 1, 2015, pp. 297-304. https://doi.org/10.1007/s00705-014-2283-0

Perić, Magdalena, Zinka Bošnjak, Bojan Šarkanj, Jerko Barbić, Arlen Antolović Požgain, Nataša Ružman, Ivana Roksandić Križan and Dubravka Vuković. "Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia." Archives of Virology 160, no. 1 (2015): 297-304. https://doi.org/10.1007/s00705-014-2283-0

Perić, M., et al. (2015) 'Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia', Archives of Virology, 160(1), pp. 297-304. doi: 10.1007/s00705-014-2283-0

Perić M, Bošnjak Z, Šarkanj B, Barbić J, Antolović Požgain A, Ružman N, and sur.. Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia. Archives of Virology [Internet]. 2015 [cited 2024 November 26];160(1):297-304. doi: 10.1007/s00705-014-2283-0

M. Perić, et al., "Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia", Archives of Virology, vol. 160, no. 1, pp. 297-304, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:131646. [Accessed: 26 November 2024]

Metadata
Title (english)Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia
AuthorMagdalena Perić
MBZ: 339363
AuthorZinka Bošnjak
MBZ: 339352
AuthorBojan Šarkanj
MBZ: 300455
AuthorJerko Barbić
MBZ: 258420
AuthorArlen Antolović-Požgain
MBZ: 338395
AuthorNataša Ružman
AuthorIvana Roksandić-Križan
MBZ: 315592
AuthorDubravka Vuković
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Chronic infection with hepatitis C virus (HCV) is caused by an inadequate immune response. Experimental data suggest that the impaired activation of Toll-like receptors (TLRs) 2 and 4 contributes to chronic infection. We assessed the distribution of three single-nucleotide polymorphisms (SNPs) in the TLR2 (Arg753Gln) and TLR4 (Asp299Gly/Thr399Ile) genes in individuals from north-east Croatia and their effect on the outcome of antiviral therapy. The study consisted of 60 chronically infected patients and 40 healthy subjects. TLR polymorphisms were determined by the PCR-based melting curve analysis. HCV genotyping was performed using the Linear Array Hepatitis C Virus Genotyping Test. Thirty-three patients were treated with standard interferon and ribavirin therapy, and their viral load was evaluated at weeks 28 and 53 after the beginning of therapy. The majority of chronic infections were caused by genotype 1 (77%), followed by genotypes 3 (15%) and 4 (7%). Patients with genotype 1 had higher viral loads than patients infected with other genotypes (P = 0.0428). Healthy individuals and patients with chronic infection had similar frequencies of TLR2-Arg753Gln and TLR4-Asp299Gly/Thr399Ile SNPs. Heterozygous and homozygous TLR4-Asp299Gly/Thr399Ile polymorphisms correlated with higher viral loads and delayed responses to antiviral therapy. We have provided the first evidence that TLR4 polymorphisms influence the success of antiviral therapy in our region. This suggests that therapeutic strategies should be adjusted not only according to HCV genotype but also to individual TLR polymorphism(s).
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArchives of Virology
Numberingvol. 160, no. 1, pp. 297-304
p-ISSN0304-8608
e-ISSN1432-8798
DOIhttps://doi.org/10.1007/s00705-014-2283-0
URN:NBNurn:nbn:hr:239:131646
Publication2015
Document URLhttps://link.springer.com/article/10.1007%2Fs00705-014-2283-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-10-31 09:07:58