prikaz prve stranice dokumenta Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study
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Scientific paper - Original scientific paper
Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study
Mediators of Inflammation, 2019 (2019); 1-18. https://doi.org/10.1155/2019/6715275
Mihalj, Martina; Matić, Anita; Mihaljević, Zrinka; Barić, Lidija; Stupin, Ana; Drenjančević, Ines

Institutional repository: Repository UHC Osijek

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Mihalj, M., Matić, A., Mihaljević, Z., Barić, L., Stupin, A. & Drenjančević, I. (2019). Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study. Mediators of Inflammation, 2019., 1-18. doi: 10.1155/2019/6715275

Mihalj, Martina, et al. "Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study." Mediators of Inflammation, vol. 2019, 2019, pp. 1-18. https://doi.org/10.1155/2019/6715275

Mihalj, Martina, Anita Matić, Zrinka Mihaljević, Lidija Barić, Ana Stupin and Ines Drenjančević. "Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study." Mediators of Inflammation 2019 (2019): 1-18. https://doi.org/10.1155/2019/6715275

Mihalj, M., et al. (2019) 'Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study', Mediators of Inflammation, 2019, pp. 1-18. doi: 10.1155/2019/6715275

Mihalj M, Matić A, Mihaljević Z, Barić L, Stupin A, Drenjančević I. Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study. Mediators of Inflammation [Internet]. 2019 [cited 2024 November 22];2019:1-18. doi: 10.1155/2019/6715275

M. Mihalj, A. Matić, Z. Mihaljević, L. Barić, A. Stupin and I. Drenjančević, "Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study", Mediators of Inflammation, vol. 2019, pp. 1-18, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:810271. [Accessed: 22 November 2024]

Metadata
Title (english)Short-Term High-NaCl Dietary Intake Changes Leukocyte Expression of VLA-4, LFA-1, and Mac-1 Integrins in Both Healthy Humans and Sprague-Dawley Rats: a Comparative Study
AuthorMartina Mihalj
MBZ: 322792
AuthorAnita Matić
MBZ: 326344
AuthorZrinka Mihaljević
MBZ: 324952
AuthorLidija Barić
AuthorAna Stupin
MBZ: 322935
AuthorInes Drenjančević
MBZ: 209603
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Dietotherapy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Abstract (english)
This study is aimed at assessing the effects of a short-term high-salt (HS) diet on the peripheral blood leukocyte (PBL) activation status in healthy rats and young human individuals. Distribution of PBL subpopulations and surface expression of integrins were determined using flow cytometry in 36 men and women on a 7-day low-salt diet (<3.2 g salt/day) immediately followed by a 7-day HS diet (~14 g salt/day) or in Sprague-Dawley (SD) rats (n = 24) on a 0.4% NaCl diet (aLS group) or a 4% NaCl diet (aHS group) for 7 days. The aHS group presented with an increased frequency of granulocytes, while the frequency of lymphocytes was reduced. Although in humans HS diet reduced the expression of CD11b(act) integrin on lymphocytes, the frequency of CD11b(act)-bearing cells among all PBL subsets was increased. The aHS group of rats exhibited increased expression of total CD11b/c in granulocytes and CD3 lymphocytes. The expression of CD11a was significantly reduced in all PBL subsets from human subjects and increased in the aHS group. CD49d expression on all PBL subsets was significantly decreased in both humans and rats. In human subjects, we found reduced frequencies of intermediate monocytes accompanied by a reciprocal increase in classical monocytes. Present results suggest that a short-term HS diet can alter leukocytes' activation status and promote vascular low-grade inflammation.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMediators of Inflammation
Numberingvol. 2019, pp. 1-18
p-ISSN0962-9351
e-ISSN1466-1861
DOIhttps://doi.org/10.1155/2019/6715275
URN:NBNurn:nbn:hr:239:810271
Publication2019
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766117/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-17 13:33:35