prikaz prve stranice dokumenta Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome
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Scientific paper - Original scientific paper
Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome
International Journal of Environmental Research and Public Health, 15 (2018), 7; 1-7. https://doi.org/10.3390/ijerph15071486
Vukšić Polić, Melita; Miškulin, Maja; Smolić, Martina; Kralik, Kristina; Miškulin, Ivan; Cigrovski Berković, Maja; Bilić Ćurčić, Ines

Institutional repository: Repository UHC Osijek

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Vukšić Polić, M., Miškulin, M., Smolić, M., Kralik, K., Miškulin, I., Cigrovski Berković, M. & Bilić Ćurčić, I. (2018). Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome. International Journal of Environmental Research and Public Health, 15. (7), 1-7. doi: 10.3390/ijerph15071486

Vukšić Polić, Melita, et al. "Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome." International Journal of Environmental Research and Public Health, vol. 15, no. 7, 2018, pp. 1-7. https://doi.org/10.3390/ijerph15071486

Vukšić Polić, Melita, Maja Miškulin, Martina Smolić, Kristina Kralik, Ivan Miškulin, Maja Cigrovski Berković and Ines Bilić Ćurčić. "Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome." International Journal of Environmental Research and Public Health 15, no. 7 (2018): 1-7. https://doi.org/10.3390/ijerph15071486

Vukšić Polić, M., et al. (2018) 'Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome', International Journal of Environmental Research and Public Health, 15(7), pp. 1-7. doi: 10.3390/ijerph15071486

Vukšić Polić M, Miškulin M, Smolić M, Kralik K, Miškulin I, Cigrovski Berković M, and sur.. Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome. International Journal of Environmental Research and Public Health [Internet]. 2018 [cited 2024 December 26];15(7):1-7. doi: 10.3390/ijerph15071486

M. Vukšić Polić, et al., "Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome", International Journal of Environmental Research and Public Health, vol. 15, no. 7, pp. 1-7, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:395050. [Accessed: 26 December 2024]

Metadata
Title (english)Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome
AuthorMelita Vukšić Polić
MBZ: 316624
AuthorMaja Miškulin
MBZ: 290921
AuthorMartina Smolić
MBZ: 292155
AuthorKristina Kralik
AuthorIvan Miškulin
MBZ: 350925
AuthorMaja Cigrovski Berković
MBZ: 314071
AuthorInes Bilić Ćurčić
MBZ: 268184
Author's institution(Clinical hospital center Osijek)
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
BACKGROUND: It is still debatable whether psoriasis increases cardiovascular risk indirectly since it is associated with metabolic syndrome or is an independent cardiovascular risk factor. The aim of this study was to evaluate psoriasis severity as an independent predictor of insulin resistance (IR) irrespective of the presence of metabolic syndrome (MetS). METHODS: This was a case control study including 128 patients stratified into two groups: patients with psoriasis and metabolic syndrome vs. patients with psoriasis and no metabolic syndrome. MetS was diagnosed according to ATP III criteria with homeostatic model assessment of insulin resistance (HOMA-IR), as well as a homeostatic model assessment of beta cell function (HOMA-β) were calculated. RESULTS: Compared to subjects without metabolic syndrome, patients with metabolic syndrome had a significantly higher Psoriasis Area Severity Index (PASI) values (p < 0.001). The strongest correlation was established for HOMA-IR and the PASI index (p < 0.001), even after adjustment for body mass index (BMI) in regression analysis model. In patients without MetS and severe forms of disease, the HOMA-IR and HOMA-β values were significantly higher compared to mild forms of disease (p < 0.001 for all) while in subjects with MetS no difference was established for HOMA-IR or HOMA-β based on disease severity. CONCLUSIONS: Psoriasis severity is an independent risk factor of HOMA-IR, the strongest association being present in the non-MetS group, who still had preserved beta cell function suggesting direct promotion of atherosclerosis via insulin resistance depending on the disease severity, but irrespective of the presence of metabolic syndrome.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Environmental Research and Public Health
Numberingvol. 15, no. 7, pp. 1-7
e-ISSN1660-4601
DOIhttps://doi.org/10.3390/ijerph15071486
URN:NBNurn:nbn:hr:239:395050
Publication2018
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069377/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-17 14:03:51