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Scientific paper - Original scientific paper
Differential Expression of TFF Genes and Proteins in Breast Tumors
Acta clinica Croatica, 57 (2018), 2; 264-277. https://doi.org/10.20471/acc.2018.57.02.06
Tolušić Levak, Maja; Mihalj, Martina; Koprivčić, Ivan; Lovrić, Ivana; Novak, Sanja; Bijelić, Nikola; Baus-Lončar, Mirela; Belovari, Tatjana; Kralik, Kristina; Pauzar, Biljana

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Tolušić Levak, M., Mihalj, M., Koprivčić, I., Lovrić, I., Novak, S., Bijelić, N. ... Pauzar, B. (2018). Differential Expression of TFF Genes and Proteins in Breast Tumors. Acta clinica Croatica, 57. (2), 264-277. doi: 10.20471/acc.2018.57.02.06

Tolušić Levak, Maja, et al. "Differential Expression of TFF Genes and Proteins in Breast Tumors." Acta clinica Croatica, vol. 57, no. 2, 2018, pp. 264-277. https://doi.org/10.20471/acc.2018.57.02.06

Tolušić Levak, Maja, Martina Mihalj, Ivan Koprivčić, Ivana Lovrić, Sanja Novak, Nikola Bijelić, Mirela Baus Lončar, Tatjana Belovari, Kristina Kralik and Biljana Pauzar. "Differential Expression of TFF Genes and Proteins in Breast Tumors." Acta clinica Croatica 57, no. 2 (2018): 264-277. https://doi.org/10.20471/acc.2018.57.02.06

Tolušić Levak, M., et al. (2018) 'Differential Expression of TFF Genes and Proteins in Breast Tumors', Acta clinica Croatica, 57(2), pp. 264-277. doi: 10.20471/acc.2018.57.02.06

Tolušić Levak M, Mihalj M, Koprivčić I, Lovrić I, Novak S, Bijelić N, and sur.. Differential Expression of TFF Genes and Proteins in Breast Tumors. Acta clinica Croatica [Internet]. 2018 [cited 2024 May 21];57(2):264-277. doi: 10.20471/acc.2018.57.02.06

M. Tolušić Levak, et al., "Differential Expression of TFF Genes and Proteins in Breast Tumors", Acta clinica Croatica, vol. 57, no. 2, pp. 264-277, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:128292. [Accessed: 21 May 2024]

Metadata
Title (english)Differential Expression of TFF Genes and Proteins in Breast Tumors
AuthorMaja Tolušić Levak
MBZ: 338680
AuthorMartina Mihalj
MBZ: 322792
AuthorIvan Koprivčić
MBZ: 311933
AuthorIvana Lovrić
AuthorSanja Novak
MBZ: 326355
AuthorNikola Bijelić
MBZ: 313935
AuthorMirela Baus-Lončar
MBZ: 222563
AuthorTatjana Belovari
MBZ: 209063
AuthorKristina Kralik
AuthorBiljana Pauzar
MBZ: 209910
Author's institutionRuđer Bošković Institute
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and TFF genes with clinical and pathologic characteristics of the tumor. Study group included 122 patients with surgically removed breast tumors. Samples were investigated using qRT-PCR and immunohistochemistry. TFF1 and TFF3 genes and proteins were expressed in breast tumors, while the levels of TFF2 gene and protein expression were very low or undetectable. TFF1 was significantly more expressed in benign tumors, while TFF3 was more expressed in malignant tumors. Gene and protein expression of both TFF1 and TFF3 was greater in lymph node-negative tumors, hormone positive tumors, tumors with moderate levels of Ki67 expression, and in grade II tumors. A strong positive correlation was found between TFF1 and TFF3 genes, and the expression of both negatively correlated with Ki67 and the level of tumor histologic differentiation. Our results suggest that TFF1 and TFF3, but not TFF2, may have a role in breast tumor pathogenesis and could be used in the assessment of tumor differentiation and malignancy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 57, no. 2, pp. 264-277
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2018.57.02.06
URN:NBNurn:nbn:hr:239:128292
Publication2018
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532012/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) icon
Created on2020-01-21 12:24:18