prikaz prve stranice dokumenta Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death
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Scientific paper - Original scientific paper
Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death
Acta clinica Croatica, 58 (2019), 3; 446-454. https://doi.org/10.20471/acc.2019.58.03.07
Kardum, Darjan; Filipović-Grčić, Boris; Muller, Andrijana; Dessardo, Sandro

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Kardum, D., Filipović Grčić, B., Muller, A. & Dessardo, S. (2019). Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death. Acta clinica Croatica, 58. (3), 446-454. doi: 10.20471/acc.2019.58.03.07

Kardum, Darjan, et al. "Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death." Acta clinica Croatica, vol. 58, no. 3, 2019, pp. 446-454. https://doi.org/10.20471/acc.2019.58.03.07

Kardum, Darjan, Boris Filipović Grčić, Andrijana Muller and Sandro Dessardo. "Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death." Acta clinica Croatica 58, no. 3 (2019): 446-454. https://doi.org/10.20471/acc.2019.58.03.07

Kardum, D., et al. (2019) 'Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death', Acta clinica Croatica, 58(3), pp. 446-454. doi: 10.20471/acc.2019.58.03.07

Kardum D, Filipović Grčić B, Muller A, Dessardo S. Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death. Acta clinica Croatica [Internet]. 2019 [cited 2024 December 24];58(3):446-454. doi: 10.20471/acc.2019.58.03.07

D. Kardum, B. Filipović Grčić, A. Muller and S. Dessardo, "Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death", Acta clinica Croatica, vol. 58, no. 3, pp. 446-454, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:455341. [Accessed: 24 December 2024]

Metadata
Title (english)Survival Until Discharge of Very-low-birth-weight Infants in two Croatian Perinatal Care Regions: a Retrospective Cohort Study of Time and Cause of Death
Title (croatian)Preživljenje do otpusta iz bolnice novorođenčadi vrlo niske porođajne težine u dvije hrvatske perinatalne regije: retrospektivna studija vremena i uzroka smrti
AuthorDarjan Kardum
MBZ: 348236
AuthorBoris Filipović-Grčić
MBZ: 138143
AuthorAndrijana Muller
MBZ: 294701
AuthorSandro Dessardo
MBZ: 257426
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Author's institutionUniversity of Rijeka
Faculty of Medicine
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
We investigated mortality, causes, timing and risk factors for death until hospital discharge in very-low-birth-weight (VLBW) infants born in two Croatian perinatal care regions. This retrospective study included 252 live born VLBW infants. The mortality rate until hospital discharge was 30.5% (77/252). VLBW in-fants who died had by 4 weeks lower gestational age (GA) than surviving infants (median GA, 25 vs. 29 weeks), lower birth weight (BW) (mean BW, 756.4 vs. 1126.4 g), lower 5-minute Apgar score (median 5 vs. 8) and were more often resuscitated at birth (41.6 vs. 19.4%; p<0.001 all). Infants who survived were more often small-for-gestational age (SGA) (28.0 vs. 15.6%; p=0.04) and more often received continuous-positive-airway-pressure (CPAP) in delivery room (13.1 vs. 2.6%; p=0.01). Multivariate logistic regression revealed that parameters influencing death until hospital discharge were 5-minute Apgar score (OR 0.780, 95% CI 0.648-0.939) and higher Clinical Risk Index for Babies (CRIB) score (OR 1.677, 95% CI 1.456-1.931). ROC analysis showed that CRIB score (AUC 0.927, sensitivity 92.2, specificity 81.1; p<0.001) was the strongest predictor of death until hospital discharge. In infants who died within 12 hours, death was most commonly attributed to immaturity and in those surviving >12 hours to necrotizing enterocolitis.
Abstract (croatian)
Istraživali smo smrtnost, uzroke, vrijeme i rizične čimbenike za smrt do otpusta iz bolnice u novorođenčadi vrlo niske porođajne težine (VNPT) rođene u dvije hrvatske perinatalne regije. Ova retrospektivna studija je uključila 252 živo-rođena novorođenčeta VNPT. Smrtnost do otpusta iz bolnice bila je 30.5% (77/252). Novorođenčad VNPT koja su umrla bila su 4 tjedna manje gestacijske dobi od novorođenčadi koja je preživjela (medijan gestacijske dobi 25 prema 29 tjedana; p<0,001), imala su manju porođajnu težinu (srednja vrijednost 756,4 prema 1126,4 g; p<0,001), niže vrijednosti Apgar zbroja u 5. minuti života (medijan 5 prema 8; p<0,001) i češće su bila reanimirana pri porođa-ju (41,6% prema 19,4%; p<0,001). Preživjela novorođenčad su češće bila mala za gestacijsku dob (28,0% prema 15,6%; p=0,04) i kod njih je češće primijenjen kontinuirani pozitivni tlak u rađaonici (13,1% prema 2,6%; p=0,01). Multivarijatna logistička regresija je pokazala da su parametri koji najsnažnije utječu na smrt do otpusta iz bolnice Apgar zbroj u 5. minuti (OR 0,780, 95% CI 0,648-0,939) i CRIB zbroj (Critical Risk Index for Babies) (OR 1,677, 95% CI 1,456-1,931). ROC analiza je pokazala kako je CRIB zbroj (AUC 0,927, osjetljivost 92,2, specifičnost 81,1; p<0,001) najznačajniji prediktor smrti do otpusta iz bolnice. Nezrelost je glavni uzrok smrti u novorođenčadi koja su umrla prije 12. sata hospitalizacije. U novorođenčadi koja je preživjela >12 sati glavni uzrok smrti je nekrotizirajući enterokolitis.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 58, no. 3, pp. 446-454
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2019.58.03.07
URN:NBNurn:nbn:hr:239:455341
Publication2019
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=334651
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-03-27 10:36:56