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Scientific paper - Original scientific paper
The Significance of Helicobacter pylori in Patients with Nasal Polyposis
Medicinski glasnik, 9 (2012), 2; 281-286. urn:nbn:hr:239:387998
Včeva, Andrijana; Đanić, Davorin; Včev, Aleksandar; Birtić, Darija; Mihalj, Hrvoje; Zubčić, Željko; Kotromanović, Željko; Hadžibegović Đanić, Ana

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Včeva, A., Đanić, D., Včev, A., Birtić, D., Mihalj, H., Zubčić, Ž. ... Hadžibegović Đanić, A. (2012). The Significance of Helicobacter pylori in Patients with Nasal Polyposis. Medicinski glasnik, 9. (2), 281-286. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:387998

Včeva, Andrijana, et al. "The Significance of Helicobacter pylori in Patients with Nasal Polyposis." Medicinski glasnik, vol. 9, no. 2, 2012, pp. 281-286. https://urn.nsk.hr/urn:nbn:hr:239:387998

Včeva, Andrijana, Davorin Đanić, Aleksandar Včev, Darija Birtić, Hrvoje Mihalj, Željko Zubčić, Željko Kotromanović and Ana Hadžibegović Đanić. "The Significance of Helicobacter pylori in Patients with Nasal Polyposis." Medicinski glasnik 9, no. 2 (2012): 281-286. https://urn.nsk.hr/urn:nbn:hr:239:387998

Včeva, A., et al. (2012) 'The Significance of Helicobacter pylori in Patients with Nasal Polyposis', Medicinski glasnik, 9(2), pp. 281-286. Available at: https://urn.nsk.hr/urn:nbn:hr:239:387998 (Accessed 18 February 2025)

Včeva A, Đanić D, Včev A, Birtić D, Mihalj H, Zubčić Ž, and sur.. The Significance of Helicobacter pylori in Patients with Nasal Polyposis. Medicinski glasnik [Internet]. 2012 [cited 2025 February 18];9(2):281-286. Available at: https://urn.nsk.hr/urn:nbn:hr:239:387998

A. Včeva, et al., "The Significance of Helicobacter pylori in Patients with Nasal Polyposis", Medicinski glasnik, vol. 9, no. 2, pp. 281-286, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:387998. [Accessed: 18 February 2025]

Metadata
Title (english)The Significance of Helicobacter pylori in Patients with Nasal Polyposis
Title (croatian)Značaj Helicobacter pylori u bolesnika s nosnom polipozom
AuthorAndrijana Včeva
MBZ: 239496
AuthorDavorin Đanić
MBZ: 130651
AuthorAleksandar Včev
MBZ: 141721
AuthorDarija Birtić
MBZ: 342581
AuthorHrvoje Mihalj
MBZ: 347871
AuthorŽeljko Zubčić
MBZ: 345090
AuthorŽeljko Kotromanović
AuthorAna Hadžibegović Đanić
MBZ: 345663
Author's institution(Clinical hospital center Osijek)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
Aim To determine the presence of Helicobacter pylori in nasal polyps and the transmission of H. pylori from stomach to nasal polyps. Methods In a prospective, controlled clinical research, 35 subjects with nasal polyps and 30 controls with concha bullosa (CB) were involved, and had been subjected to endoscopic sinus surgery (ESS). In the biopsies of removed polyps and CB, polymerase chain reaction (PCR) was used for detecting the H. pylori DNA. Blood samples of the test and control group were evaluated for H. pylori immunoglobulin (Ig) G and A antibodies by ELISA. The test and control group underwent esophagogastroduodenoscopy with taking biopsies from the stomach for PCR detection of H. pylori DNA. Results In blood samples, specific IgG and IgA antibodies to H. pylori were found in 30 (85.71%) of 35 polyp patients and in 16 (53.33%) of 30 controls. In 10 (28.57%) of 35 patients H. pylori DNA was identified in the nasal polyp tissue, but it was not detected in the CB specimens. H. pylori DNA was found in the stomach mucosa samples of all test and control group of subjects. Significant statistical difference was found in the H.pylori specific IgG and IgA between the test and control group (p<0.006) and between the polyp and control biopsy specimens of H. pylori DNA by PCR (p<0.001). Conclusion This research points to the colonisation of nasal polyps with H. pylori, the transfer of H. pylori from stomach to nasal polyps and potential role of H. pylori in emergence of nasal polyps.
Abstract (croatian)
Cilj Utvrditi prisutnost Helicobacter pylori u nosnim polipima i utvrditi prijenos H. pylori iz želuca u nosne polipe. Metode U prospektivno, kontrolirano kliničko istraživanje, uključeno je 35 ispitanika s nosnom polipozom i 30 kontrolnih ispitanika s buloznom srednjom nosnom školjkom, a koji su podvrgnuti endoskopskoj sinusnoj kirurgiji (ESS). U biopsijama odstranjenih polipa i sluznice bulozne srednje nosne školjke, PCR-om je utvrđivana prisutnost H. pylori DNA. Uzorci krvi testne i kontrolne grupe ispitanika analizirani su na prisutnost specifičnih H. pylori protutijela klase IgG i IgA ELISA testom. I testnoj i kontrolnoj grupi ispitanika učinjena je ezofagogastroduodenoskopija s uzimanjem biopsija iz želuca radi PCR određivanja H. pylori DNA. Rezultati U uzorcima krvi, H. pylori specifična protutijela klase IgG i IgA, pronađena su u 30 (85,71%) od 35 pacijenata s polipima, i u 16 (53,33%) od 30 kontrolnih ispitanika. U 10 (28,57%) od 35 pacijenata H. pylori DNA je otkrivena u tkivu nosnih polipa, ali nije otkrivena u uzorcima srednje nosne školjke. H. pylori DNA otkrivena je u uzorcima sluznice želuca u svih ispitanika testne i kontrolne grupe. Postoji statistički značajna razlika u ELISA dobivenim vrijednostima H. pylori protutijela IgG i IgA između pacijenata s nosnim polipima i kontrolne grupe (p<0.006). Također, postoji statistički značajna razlika u PCR detekciji H. pylori DNA između bioptičkih uzoraka polipa i kontrolnih bioptičkih uzoraka (p<0.001). Zaključak Ovo istraživanje ukazuje na kolonizaciju nosnih polipa s H. pylori, na put prijenosa H. pylori iz želuca u nosne polipe, te na moguću ulogu H. pylori u nastanku nosnih polipa.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicinski glasnik
Numberingvol. 9, no. 2, pp. 281-286
p-ISSN1840-0132
e-ISSN1840-2445
URN:NBNurn:nbn:hr:239:387998
Publication2012
Document URLhttps://www.academia.edu/16100922/The_significance_of_Helicobacter_pylori_in_patients_with_nasal_polyposis
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-04-17 07:24:08