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Scientific paper - Original scientific paper
Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs
European Journal of Clinical Pharmacology, 70 (2014), 4; 483-490. https://doi.org/10.1007/s00228-014-1648-3
Mimica Matanović, Suzana; Vlahović-Palčevski, Vera

Institutional repository: Repository UHC Osijek

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Mimica Matanović, S. & Vlahović Palčevski, V. (2014). Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs. European Journal of Clinical Pharmacology, 70. (4), 483-490. doi: 10.1007/s00228-014-1648-3

Mimica Matanović, Suzana and Vera Vlahović Palčevski. "Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs." European Journal of Clinical Pharmacology, vol. 70, no. 4, 2014, pp. 483-490. https://doi.org/10.1007/s00228-014-1648-3

Mimica Matanović, Suzana and Vera Vlahović Palčevski. "Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs." European Journal of Clinical Pharmacology 70, no. 4 (2014): 483-490. https://doi.org/10.1007/s00228-014-1648-3

Mimica Matanović, S. and Vlahović Palčevski, V. (2014) 'Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs', European Journal of Clinical Pharmacology, 70(4), pp. 483-490. doi: 10.1007/s00228-014-1648-3

Mimica Matanović S, Vlahović Palčevski V. Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs. European Journal of Clinical Pharmacology [Internet]. 2014 [cited 2024 November 09];70(4):483-490. doi: 10.1007/s00228-014-1648-3

S. Mimica Matanović and V. Vlahović Palčevski, "Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs", European Journal of Clinical Pharmacology, vol. 70, no. 4, pp. 483-490, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:912433. [Accessed: 09 November 2024]

Metadata
Title (english)Potentially Inappropriate Prescribing to the Elderly: Comparison of new Protocol to Beers Criteria With Relation to Hospitalizations for ADRs
AuthorSuzana Mimica Matanović
MBZ: 292855
AuthorVera Vlahović-Palčevski
MBZ: 194575
Author's institution(Clinical hospital center Osijek)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Screening tools for detecting potentially inappropriate medications (PIMs) represent an important way to assess drug prescribing in the elderly. Recently, we introduced a new comprehensive tool to detect both PIMs and clinically important drug-drug interactions (DDI). The aim of the study was to assess the applicability of the new tool.The new tool was used to detect PIMs and DDI and to assess their relation to morbidity and hospital admissions. It was also compared to the widely used Beers criteria. The study population included 454 consecutive patients aged ≥65 years who were acutely admitted to the Department of Internal Medicine of the University Hospital of Osijek. The Naranjo protocol was used to analyze the causal relationship between a drug and an adverse event.According to the new protocol, 44 % patients were taking PIMs, while 33 % patients were taking drugs with potentially serious DDIs. In 11 % of the overall number of patients, the cause of admission was adverse drug reaction (ADR), and among contributing drugs, 44 % were potentially inappropriate according to our protocol. Gastrointestinal bleeding was the most common diagnosis causing ADR-associated admission, and in 72 % cases, either PIM or a potentially serious DDI was involved.The new Croatian tool detected a high number of patients taking PIMs and/or having potentially important drug-drug interactions. The tool also detected almost half of the drugs contributing to ADR-associated admission. We expect the tool to be useful in prescription evaluation for the elderly inpatient and outpatient population.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Clinical Pharmacology
Numberingvol. 70, no. 4, pp. 483-490
p-ISSN0031-6970
e-ISSN1432-1041
DOIhttps://doi.org/10.1007/s00228-014-1648-3
URN:NBNurn:nbn:hr:239:912433
Publication2014
Document URLhttps://europepmc.org/article/med/24458542
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-05-22 08:04:40