prikaz prve stranice dokumenta The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus
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Scientific paper - Original scientific paper
The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus
Clinical hemorheology and microcirculation, 71 (2019), 4; 475-481. https://doi.org/10.3233/ch-180422
Blaslov, Kristina; Kruljac, Ivan; Mirošević, Gorana; Gaćina, Petar; Kolonić, Slobodanka Ostojić; Vrkljan, Milan

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Blaslov, K., Kruljac, I., Mirošević, G., Gaćina, P., Kolonić, S. O. & Vrkljan, M. (2019). The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus. Clinical hemorheology and microcirculation, 71. (4), 475-481. doi: 10.3233/ch-180422

Blaslov, Kristina, et al. "The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus." Clinical hemorheology and microcirculation, vol. 71, no. 4, 2019, pp. 475-481. https://doi.org/10.3233/ch-180422

Blaslov, Kristina, Ivan Kruljac, Gorana Mirošević, Petar Gaćina, Slobodanka Ostojić Kolonić and Milan Vrkljan. "The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus." Clinical hemorheology and microcirculation 71, no. 4 (2019): 475-481. https://doi.org/10.3233/ch-180422

Blaslov, K., et al. (2019) 'The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus', Clinical hemorheology and microcirculation, 71(4), pp. 475-481. doi: 10.3233/ch-180422

Blaslov K, Kruljac I, Mirošević G, Gaćina P, Kolonić SO, Vrkljan M. The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus. Clinical hemorheology and microcirculation [Internet]. 2019 [cited 2024 November 09];71(4):475-481. doi: 10.3233/ch-180422

K. Blaslov, I. Kruljac, G. Mirošević, P. Gaćina, S. O. Kolonić and M. Vrkljan, "The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus", Clinical hemorheology and microcirculation, vol. 71, no. 4, pp. 475-481, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:544502. [Accessed: 09 November 2024]

Metadata
Title (english)The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus
AuthorKristina Blaslov
AuthorIvan Kruljac
AuthorGorana Mirošević
AuthorPetar Gaćina
AuthorSlobodanka Ostojić Kolonić
AuthorMilan Vrkljan
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
BACKGROUND: Although it is considered that the pathogenesis of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) is primarily due to chronic hyperglycemia resulting in vascular changes and retinal ischemia, the red blood cells (RBCs) disorders might also represent an important pathophysiological risk factor. OBJECTIVE: To evaluate whether the RBC properties contribute to DR development and progression in T2DM. METHODS: This prospective observational study comprised 247 persons with T2DM free of DR or with non proliferative DR without any signs of anaemia. The patients were reacessed after 60-months. RESULTS: The mean age of our study population was 56 years, 54.9% males with diabetes duration of 11, 18±1, 28 years. During the follow up, 16 (5.84%) participants developed non proliferative DR and 9 (3.64%) progressed to PDR while the mean corpuscular volume (MCV) and red cell distribution width (RDW) MCV rose. Both MCV and RDW correlated positively with HbA1c (r = 0, 468, p = 0.003 and r = 0.521, p < 0.001), while Cox regression analysis revealed that besides age, diabetes duration, HbA1c, hypertension and dyslipidemia presence, MCV and RDW are also associated with the risk of DR development and progression (HR 1.057 and 1.237, p < 0.001). CONCLUSIONS: We clearly demonstrated that RBC's characteristics might represent a risk factor for DR development and progression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical hemorheology and microcirculation
Numberingvol. 71, no. 4, pp. 475-481
p-ISSN1386-0291
DOIhttps://doi.org/10.3233/ch-180422
URN:NBNurn:nbn:hr:220:544502
Publication2019
Document URLhttps://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180422
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-06-28 07:28:41