prikaz prve stranice dokumenta Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet
  Download
PDF 76.24 KB
Scientific paper - Original scientific paper
Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet
Collegium antropologicum, 28 (2004), 2; 631-637. urn:nbn:hr:220:923026
Roša, Jagoda; Pancirov, Helena; Skala, Hana; Gadžić, Alan; Roša, Josip

Institutional repository: Repository of the Sestre milosrdnice University Hospital Center

Cite this document

Roša, J., Pancirov, H., Skala, H., Gadžić, A. & Roša, J. (2004). Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet. Collegium antropologicum, 28. (2), 631-637. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:923026

Roša, Jagoda, et al. "Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet." Collegium antropologicum, vol. 28, no. 2, 2004, pp. 631-637. https://urn.nsk.hr/urn:nbn:hr:220:923026

Roša, Jagoda, Helena Pancirov, Hana Skala, Alan Gadžić and Josip Roša. "Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet." Collegium antropologicum 28, no. 2 (2004): 631-637. https://urn.nsk.hr/urn:nbn:hr:220:923026

Roša, J., et al. (2004) 'Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet', Collegium antropologicum, 28(2), pp. 631-637. Available at: https://urn.nsk.hr/urn:nbn:hr:220:923026 (Accessed 06 October 2024)

Roša J, Pancirov H, Skala H, Gadžić A, Roša J. Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet. Collegium antropologicum [Internet]. 2004 [cited 2024 October 06];28(2):631-637. Available at: https://urn.nsk.hr/urn:nbn:hr:220:923026

J. Roša, H. Pancirov, H. Skala, A. Gadžić and J. Roša, "Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet", Collegium antropologicum, vol. 28, no. 2, pp. 631-637, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:923026. [Accessed: 06 October 2024]

Metadata
Title (english)Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet
AuthorJagoda Roša
AuthorHelena Pancirov
AuthorHana Skala
AuthorAlan Gadžić
AuthorJosip Roša
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Increased dietary fat intake in general, and saturated fat specifically, will lead to the impairment of insulin action. The aim of this study was to find out the changes in hepatic glucose output in dependence of fat diet and a possible direct action of insulin and troglitazone in hepatocytes. Hepatocytes were isolated by a collagenase perfusion technique and cultured for 24 h in M 199 serum-free medium. The glucose production in hepatocytes isolated from rats on high fat diet (unsaturated fat) was 79% higher compared to control and even 139% higher than in rats on high-fat diet (saturated fat). Troglitazone significantly decreased the glucose production in hepatocytes obtained from rats on unsaturated fat diet. The troglitazone in presence of insulin totally normalized glucose production but also only in hepatocytes obtained from rats on unsaturated-fat diet. The troglitazone showed an insulinomimetic as well as insulin-sensitizing effect but only in rats on unsaturated-fat diet.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 28, no. 2, pp. 631-637
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:220:923026
Publication2004
Document URLhttps://hrcak.srce.hr/5587
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-08-21 12:53:25