prikaz prve stranice dokumenta Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience
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Scientific paper - Original scientific paper
Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience
Diagnostics, 12 (2022), 4; 866. https://doi.org/10.3390/diagnostics12040866
Jukić, Tomislav; Blažeković, Ivan; Franceschi, Maja; Petranović Ovčariček, Petra; Bosak Butković, Marija; Dabelić, Nina; Granić, Roko; Punda, Marija; Sonicki, Zdenko; Vagić, Davor; Fröbe, Ana; Kusić, Zvonko

Institutional repository: Repository of the Sestre milosrdnice University Hospital Center

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Jukić, T., Blažeković, I., Franceschi, M., Petranović Ovčariček, P., Bosak Butković, M., Dabelić, N. ... Kusić, Z. (2022). Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience. Diagnostics, 12. (4). doi: 10.3390/diagnostics12040866

Jukić, Tomislav, et al. "Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience." Diagnostics, vol. 12, no. 4, 2022. https://doi.org/10.3390/diagnostics12040866

Jukić, Tomislav, Ivan Blažeković, Maja Franceschi, Petra Petranović Ovčariček, Marija Bosak Butković, Nina Dabelić, Roko Granić, et al. "Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience." Diagnostics 12, no. 4 (2022). https://doi.org/10.3390/diagnostics12040866

Jukić, T., et al. (2022) 'Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience', Diagnostics, 12(4). doi: 10.3390/diagnostics12040866

Jukić T, Blažeković I, Franceschi M, Petranović Ovčariček P, Bosak Butković M, Dabelić N, and sur.. Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience. Diagnostics [Internet]. 2022 [cited 2024 November 10];12(4). doi: 10.3390/diagnostics12040866

T. Jukić, et al., "Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience", Diagnostics, vol. 12, no. 4, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:541917. [Accessed: 10 November 2024]

Metadata
Title (english)Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience
AuthorTomislav Jukić
AuthorIvan Blažeković
AuthorMaja Franceschi
AuthorPetra Petranović Ovčariček
AuthorMarija Bosak Butković
AuthorNina Dabelić
AuthorRoko Granić
AuthorMarija Punda
AuthorZdenko Sonicki
AuthorDavor Vagić
AuthorAna Fröbe
AuthorZvonko Kusić
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Background: Indolent nature but a high incidence of differentiated thyroid cancer (DTC) remains a challenge for optimizing patient care. Therefore, prognostic factors present valuable information for determining an adequate clinical approach. Methods: This study assessed prognostic features of 1167 papillary (PTC) and 215 follicular (FTC) thyroid cancer patients that had undergone surgery between 1962 and 2012, and were followed-up up to 50 years in a single institution, till April 2020. Age, gender, tumor size, presence of local and distant metastases at presentation, extrathyroidal extension, disease recurrence, and cancer-specific survival were evaluated. Results: In multivariate analysis, factors affecting the worse outcome were age (p = 0.005), tumor size (p = 0.006), and distant metastases (p = 0.001) in PTC, while extrathyroidal extension (p < 0.001), neck recurrence (p = 0.002), and distant metastases (p < 0.001) in FTC patients. Loco-regional recurrence rate was 6% for PTC and 4.7% for FTC patients, while distant metastases were detected in 4.2% PTC and 14.4% of FTC patients. The 10-year cancer-specific survival rates for PTC and FTC were 98.6% and 89.8%, respectively (p < 0.001). Conclusions: Negative prognostic factors, besides distant metastases, were older age and greater tumor size in PTC, and extrathyroidal extension and neck recurrence in FTC patients. The recurrence and mortality rates were very low.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 12, no. 4, 866
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12040866
URN:NBNurn:nbn:hr:220:541917
Publication2022
Document URLhttps://www.mdpi.com/2075-4418/12/4/866
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-05 09:58:24