prikaz prve stranice dokumenta Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report
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Scientific paper - Case study
Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report
Acta clinica Croatica, 62 (2023), 1; 234-240. https://doi.org/10.20471/acc.2023.62.01.28
Sesar, Nikolina; Splavski, Bruno; Gamulin, Marija; Rotim, Krešimir

Institutional repository: Repository of the Sestre milosrdnice University Hospital Center

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Sesar, N., Splavski, B., Gamulin, M. & Rotim, K. (2023). Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report. Acta clinica Croatica, 62. (1), 234-240. doi: 10.20471/acc.2023.62.01.28

Sesar, Nikolina, et al. "Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report." Acta clinica Croatica, vol. 62, no. 1, 2023, pp. 234-240. https://doi.org/10.20471/acc.2023.62.01.28

Sesar, Nikolina, Bruno Splavski, Marija Gamulin and Krešimir Rotim. "Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report." Acta clinica Croatica 62, no. 1 (2023): 234-240. https://doi.org/10.20471/acc.2023.62.01.28

Sesar, N., et al. (2023) 'Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report', Acta clinica Croatica, 62(1), pp. 234-240. doi: 10.20471/acc.2023.62.01.28

Sesar N, Splavski B, Gamulin M, Rotim K. Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report. Acta clinica Croatica [Internet]. 2023 [cited 2024 November 06];62(1):234-240. doi: 10.20471/acc.2023.62.01.28

N. Sesar, B. Splavski, M. Gamulin and K. Rotim, "Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report", Acta clinica Croatica, vol. 62, no. 1, pp. 234-240, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:661081. [Accessed: 06 November 2024]

Metadata
Title (english)Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report
Title (croatian)Rijetki intrakranijski multifokalni ne-germinomatozni tumor zametnih stanica kod 18-godišnjeg mladića: prikaz slučaja
AuthorNikolina Sesar
AuthorBruno Splavski
AuthorMarija Gamulin
AuthorKrešimir Rotim
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Intracranial germ cell tumors are rare brain tumors that are distinguished based on their histology and selected tumor markers. Non-germinomatous germ cell tumors are a diverse group of such tumors having the poorest prognosis. Most commonly, they are located in the suprasellar and pineal regions. Since the exact treatment protocol has not yet been established, there is currently no standardized modality of management. We present a case of intracranial multifocal non-germinomatous germ cell tumor in an 18-year-old male, along with relevant literature review. We describe initial diagnostic and treatment procedures in a young adult presented with diplopia and ataxic gait. Neuroradiological findings and elevated alpha fetoprotein and beta chain of the human chorionic gonadotropin tumor markers indicated the possible mixed germ cell tumor. Chemotherapy regimen was adjusted accordingly, biopsy was not performed. The patient’s clinical condition improved significantly and his alpha fetoprotein values decreased remarkably after initiation of chemotherapy. In conclusion, initial evaluation with neuroimaging, tumor markers, and cytology from cerebrospinal fluid is important as guidance to further treatment and prognosis. In selected cases, biopsy may not be indicated to start adjuvant chemotherapy. We emphasize the importance of specific treatment modality selection based mainly on tumor markers, regardless of the precise histologic classification.
Abstract (croatian)
Intrakranijski tumori zametnih stanica su rijetki tumori mozga koji se razlikuju na temelju histologije i tumorskih biljega. Ne-germinomatozni tumori zametnih stanica su raznolika podskupina tih tumora s najlošijom prognozom. Najčešće su locirani u supraselarnoj i pinealnoj regiji. S obzirom na to da točan protokol liječenja još nije utemeljen trenutno ne postoji standardizirani način liječenja. Predstavljamo slučaj intrakranijskog multifokalnog ne-germinomatoznog tumora zametnih stanica kod 18-godišnjeg mladića, popraćen relevantnim pregledom literature. Opisali smo početne dijagnostičke i terapijske postupke provedene kod mladića koji se prezentirao diplopijom i ataksičnim hodom. Neuroradiološki nalazi i povišeni tumorski biljezi, alfa fetoprotein te beta lanac humanog korionskog gonadotropina, upućivali su na mogući miješani tip tumora zametnih stanica. Propisana je odgovarajuća kemoterapija, a biopsija nije učinjena. Nakon početka kemoterapije bolesnikovo kliničko stanje se iznimno popravilo te su mu se vrijednosti alfa fetoproteina značajno snizile. Zaključno, početna neuroradiološka obrada, nalaz tumorskih biljega i citologija iz likvora važni su čimbenici u određivanju smjera liječenja i predviđanju prognoze. U određenim slučajevima biopsija ne mora biti indicirana kako bi se započelo s kemoterapijom. Naglašavamo važnost odabira specifičnog načina liječenja prvenstveno na temelju nalaza tumorskih biljega bez obzira na preciznu histološku klasifikaciju.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 62, no. 1, pp. 234-240
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2023.62.01.28
URN:NBNurn:nbn:hr:220:661081
Publication2023
Document URLhttps://hrcak.srce.hr/307319
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-09-11 09:04:33