prikaz prve stranice dokumenta Serotonin risk factors for the development of hypertension in pregnancy
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Scientific paper - Original scientific paper
Serotonin risk factors for the development of hypertension in pregnancy
Archives of Gynecology and Obstetrics, 291 (2014), 4; 779-785. https://doi.org/10.1007/s00404-014-3461-8
Sabolovic Rudman, Senka; Mustapic, Maja; Kosec, Vesna; Pivac, Nela; Rudman, Franjo; Muck-Seler, Dorotea

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Cite this document

Sabolovic Rudman, S., Mustapic, M., Kosec, V., Pivac, N., Rudman, F. & Muck Seler, D. (2014). Serotonin risk factors for the development of hypertension in pregnancy. Archives of Gynecology and Obstetrics, 291. (4), 779-785. doi: 10.1007/s00404-014-3461-8

Sabolovic Rudman, Senka, et al. "Serotonin risk factors for the development of hypertension in pregnancy." Archives of Gynecology and Obstetrics, vol. 291, no. 4, 2014, pp. 779-785. https://doi.org/10.1007/s00404-014-3461-8

Sabolovic Rudman, Senka, Maja Mustapic, Vesna Kosec, Nela Pivac, Franjo Rudman and Dorotea Muck Seler. "Serotonin risk factors for the development of hypertension in pregnancy." Archives of Gynecology and Obstetrics 291, no. 4 (2014): 779-785. https://doi.org/10.1007/s00404-014-3461-8

Sabolovic Rudman, S., et al. (2014) 'Serotonin risk factors for the development of hypertension in pregnancy', Archives of Gynecology and Obstetrics, 291(4), pp. 779-785. doi: 10.1007/s00404-014-3461-8

Sabolovic Rudman S, Mustapic M, Kosec V, Pivac N, Rudman F, Muck Seler D. Serotonin risk factors for the development of hypertension in pregnancy. Archives of Gynecology and Obstetrics [Internet]. 2014 [cited 2025 January 21];291(4):779-785. doi: 10.1007/s00404-014-3461-8

S. Sabolovic Rudman, M. Mustapic, V. Kosec, N. Pivac, F. Rudman and D. Muck Seler, "Serotonin risk factors for the development of hypertension in pregnancy", Archives of Gynecology and Obstetrics, vol. 291, no. 4, pp. 779-785, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:437700. [Accessed: 21 January 2025]

Metadata
Title (english)Serotonin risk factors for the development of hypertension in pregnancy
AuthorSenka Sabolovic Rudman
AuthorMaja Mustapic
AuthorVesna Kosec
AuthorNela Pivac
AuthorFranjo Rudman
AuthorDorotea Muck-Seler
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Purpose: To determine platelet serotonin (5-HT) concentrations and genotype and allele frequencies of serotonergic type 2A receptor gene (HTR2A) and 5-HT transporter gene (SLC6A4) in women with pre-eclampsia, gestational hypertension without proteinuria (PIH) and in control normotensive pregnant women. Methods: The study included 96 control women, 131 women with PIH and 84 women with pre-eclampsia (ICD-10 criteria) in the last trimester of pregnancy. Variants of the HTR2A T102C (rs6313) and SLC6A4 (5-HTTLPR and rs25531) were determined by the PCR and real-time PCR procedures. Platelet 5-HT concentrations were analyzed by the spectrofluorimetric method. Results: The frequency of the 5HTTLPR and of HTR2A T102C genotypes or alleles was similar between three groups of pregnant women and was not associated with low platelet 5-HT concentrations observed in pregnant women with PIH or pre-eclampsia. Conclusions: The results confirm alterations in the peripheral 5-HT system in pregnancy-induced hypertension. Low platelet 5-HT concentration is a common feature of both PIH and pre-eclampsia. The results did not support the hypothesis that hypertension in pregnancy is a trait associated with polymorphic variants of the HTR2A and SLC6A4 or that they have a role in the predisposition to hypertensive disorders in pregnancy. The further studies are necessary to elucidate the role of 5-HT and genetic factors in the development of hypertensive disorders in pregnancy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleArchives of Gynecology and Obstetrics
Numberingvol. 291, no. 4, pp. 779-785
p-ISSN0932-0067
e-ISSN1432-0711
DOIhttps://doi.org/10.1007/s00404-014-3461-8
URN:NBNurn:nbn:hr:220:437700
Publication2014
Document URLhttp://link.springer.com/10.1007/s00404-014-3461-8
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2024-10-18 10:18:58