prikaz prve stranice dokumenta Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite
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Scientific paper - Original scientific paper
Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite
Anticancer Research, 23 (2003), 2B; 1589-1595. urn:nbn:hr:220:890987
Žarković, Neven; Žarković, Kamelija; Kralj, Marijeta; Borović, Suzana; Sabolović, Senka; Poljak-Blaži, Marija; Čipak, Ana; Pavelić, Krešimir

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Cite this document

Žarković, N., Žarković, K., Kralj, M., Borović, S., Sabolović, S., Poljak Blaži, M. ... Pavelić, K. (2003). Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite. Anticancer Research, 23. (2B), 1589-1595. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:890987

Žarković, Neven, et al. "Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite." Anticancer Research, vol. 23, no. 2B, 2003, pp. 1589-1595. https://urn.nsk.hr/urn:nbn:hr:220:890987

Žarković, Neven, Kamelija Žarković, Marijeta Kralj, Suzana Borović, Senka Sabolović, Marija Poljak Blaži, Ana Čipak and Krešimir Pavelić. "Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite." Anticancer Research 23, no. 2B (2003): 1589-1595. https://urn.nsk.hr/urn:nbn:hr:220:890987

Žarković, N., et al. (2003) 'Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite', Anticancer Research, 23(2B), pp. 1589-1595. Available at: https://urn.nsk.hr/urn:nbn:hr:220:890987 (Accessed 22 November 2024)

Žarković N, Žarković K, Kralj M, Borović S, Sabolović S, Poljak Blaži M, and sur.. Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite. Anticancer Research [Internet]. 2003 [cited 2024 November 22];23(2B):1589-1595. Available at: https://urn.nsk.hr/urn:nbn:hr:220:890987

N. Žarković, et al., "Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite", Anticancer Research, vol. 23, no. 2B, pp. 1589-1595, 2003. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:890987. [Accessed: 22 November 2024]

Metadata
Title (english)Anticancer and Antioxidative Effects of Micronized Zeolite Clinoptilolite
AuthorNeven Žarković
AuthorKamelija Žarković
AuthorMarijeta Kralj
AuthorSuzana Borović
AuthorSenka Sabolović
AuthorMarija Poljak-Blaži
AuthorAna Čipak
AuthorKrešimir Pavelić
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Treatment of cancer-bearing mice and dogs with micronized zeolite clinoptilolite (MZ) led to improvement of the overall health status, prolongation of life span and decrease of tumor size in some cases. It also reduced lipid peroxidation in the liver of mice. Materials and Methods: The experiments were performed on various tumor cell cultures and tumor-bearing animals. Immunohistochemistry was used to analyze if MZ could interfere with Doxorubicin-induced lipid peroxidation and consequential production of 4-hydroxynonenal (HNE). Results: MZ reduced the metabolic rate of cancer cells and increased binding of HNE to albumin in vitro. It selectively reduced generation of HNE in vivo in tumor stroma after Doxorubicin treatment leaving onset of lipid peroxidation intact in malignant cells. Combined treatment with Doxorubicin and MZ resulted in strong reduction of the pulmonary metastasis count increasing anticancer effects of Doxorubicin. Conclusion: Interference of MZ with lipid peroxidation might explain some of the beneficial effects of this particular zeolite in combined cancer therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAnticancer Research
Numberingvol. 23, no. 2B, pp. 1589-1595
p-ISSN0250-7005
e-ISSN1791-7530
URN:NBNurn:nbn:hr:220:890987
Publication2003
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2024-10-18 10:36:23