prikaz prve stranice dokumenta The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study
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Scientific paper - Preliminary note / Short communication
The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study
BMC Research Notes, 3 (2010), 1; 194. https://doi.org/10.1186/1756-0500-3-194
Tišlarić-Medenjak, Dubravka; Zec, Ivana; Šimundić, Ana-Maria; Sabolović-Rudman, Senka; Kos, Milan; Megla, Željka Bukovec

Institutional repository: Repository of the Sestre milosrdnice University Hospital Center

Cite this document

Tišlarić Medenjak, D., Zec, I., Šimundić, A. M., Sabolović Rudman, S., Kos, M. & Megla, Ž. B. (2010). The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study. BMC Research Notes, 3. (1). doi: 10.1186/1756-0500-3-194

Tišlarić Medenjak, Dubravka, et al. "The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study." BMC Research Notes, vol. 3, no. 1, 2010. https://doi.org/10.1186/1756-0500-3-194

Tišlarić Medenjak, Dubravka, Ivana Zec, Ana Maria Šimundić, Senka Sabolović Rudman, Milan Kos and Željka Bukovec Megla. "The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study." BMC Research Notes 3, no. 1 (2010). https://doi.org/10.1186/1756-0500-3-194

Tišlarić Medenjak, D., et al. (2010) 'The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study', BMC Research Notes, 3(1). doi: 10.1186/1756-0500-3-194

Tišlarić Medenjak D, Zec I, Šimundić AM, Sabolović Rudman S, Kos M, Megla ŽB. The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study. BMC Research Notes [Internet]. 2010 [cited 2024 November 22];3(1). doi: 10.1186/1756-0500-3-194

D. Tišlarić Medenjak, I. Zec, A. M. Šimundić, S. Sabolović Rudman, M. Kos and Ž. B. Megla, "The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study", BMC Research Notes, vol. 3, no. 1, 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:372557. [Accessed: 22 November 2024]

Metadata
Title (english)The impact of temporal variability of biochemical markers PAPP-A and free β-hCG on the specificity of the first-trimester Down syndrome screening: a Croatian retrospective study
AuthorDubravka Tišlarić-Medenjak
AuthorIvana Zec
AuthorAna-Maria Šimundić
AuthorSenka Sabolović-Rudman
AuthorMilan Kos
AuthorŽeljka Bukovec Megla
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: The variability of maternal serum biochemical markers for Down syndrome, free β-hCG and PAPP-A can have a different impact on false-positive rates between the 10+0 and 13+6 week of gestation. The study population comprised 2883 unaffected, singleton, spontaneously conceived pregnancies in Croatian women, who delivered apparently healthy child at term. Women were separated in 4 groups, dependently on the gestational week when the analyses of biochemical markers were performed. The concentrations of free β-hCG and PAPP-A in maternal serum were determined by solid-phase, enzyme-labeled chemiluminiscent immunometric assay (Siemens Immulite). Concentrations were converted to MoMs, according to centre-specific weighted regression median curves for both markers in unaffected pregnancies. The individual risks for trisomies 21, 18 and 13 were computed by Prisca 4.0 software. Findings: There were no significant differences between the sub-groups, regarding maternal age, maternal weight and the proportion of smokers. The difference in log10 MoM free β-hCG values, between the 11th and 12th gestational week, was significant (p = 0.002). The difference in log10 MoM PAPP-A values between the 11th and 12th, and between 12th and 13th week of gestation was significant (p = 0.006 and p = 0.003, respectively). False-positive rates of biochemical risk for trisomies were 16.1% before the 11th week, 12.8% in week 12th, 11.9% in week 13th and 9.9% after week 13th. The differences were not statistically significant. Conclusions: Biochemical markers (log10 MoMs) showed gestation related variations in the first-trimester unaffected pregnancies, although the variations could not be attributed either to the inaccuracy of analytical procedures or to the inappropriately settled curves of median values for the first-trimester biochemical markers.
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBMC Research Notes
Numberingvol. 3, no. 1, 194
e-ISSN1756-0500
DOIhttps://doi.org/10.1186/1756-0500-3-194
URN:NBNurn:nbn:hr:220:372557
Publication2010
Document URLhttps://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-3-194
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-18 11:56:21