The apparitions of Our Lady of Guadalupe, as one of the first officially recognized private revelations, and the Shrine of Our Lady of Guadalupe, as the most visited Marian shrine, arouse great interest among the religious and scientific public. The Guadalupan event represents a turning point in the life of pre-Columbian indigenous cultures, but also a seed of peace between the conquistadors and the indigenous population that arose through the knowledge of Our Lady of Guadalupe as the caring Mother of all people. The most important historical evidence of Our Lady's apparitions is the miraculous Image, which hides deep symbolism and numerous messages and is kept in the sanctuary on Tepeyac - the place of the encounter with the Mother. In the first part of the paper, the author presents the historical course of events on Mexican soil just before and after Our Lady's apparitions. Then she draws the conclusions from numerous scientific studies that have been carried out on the Image and the interpretation of the symbols on it, in order to convey the spiritual message that results from this event. The elaboration of the Guadalupe piety of the Mexican population in the last part of the paper shows that this phenomenon is not a closed subject and that it is of great importance for the present and especially for the family community.