Because of its importance and relevance throughout all times, the topic of pastoral care of the family and marriage is the subject of numerous studies, research, and academic writings. In this paper, we sought to assess the current state of pastoral care of the family and marriage, examine what the Magisterium of the Catholic Church says on this matter, and identify specific pastoral initiatives that could be implemented to improve the present situation. In this context, we investigated how many people still believe in the sacrament and institution of marriage, the data on the formation of new marriages, and the percentage of those initiating annulment processes. We presented in this paper what the Magisterium documents say about the pastoral care of the family and marriage on both universal and local Church levels. We covered what the Bible teaches about this issue, with special attention to the messages expressed by the current Pope Francis in his documents. We also presented several successful models of pastoral activity in the second part of the paper as concrete examples of pastoral care of the family and marriage. Among them are the Family community in the parish of Our Lady of Otok in Solin and the “2=1” (two are one) project by the Student Catholic Centre. These represent an appropriate form of pastoral and spiritual guidance for the youth, young couples, and young families.