prikaz prve stranice dokumenta Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
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Scientific paper - Chapter in Book
Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
In: Atherogenesis / Parrthasarathy, Sampath (Ed.). INTECHWEB.ORG: InTech, 2012. pp. 507-528. urn:nbn:hr:264:148910
Flegar-Meštrić, Zlata; Kardum Paro, Mirjana Mariana; Perkov, Sonja; Vidjak, Vinko; Grdić Rajković, Marija

Institutional repository: Merkur University Hospital Repository

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Flegar Meštrić, Z., Kardum Paro, M. M., Perkov, S., Vidjak, V. & Grdić Rajković, M. (2012). Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis. In S. Parrthasarathy, (Ed.), Atherogenesis (pp. 507-528). INTECHWEB.ORG: InTech. Retrieved from https://urn.nsk.hr/urn:nbn:hr:264:148910

Flegar Meštrić, Zlata, et al. "Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis." Atherogenesis, edited by Sampath Parrthasarathy, InTech, 2012, pp. 507-528. https://urn.nsk.hr/urn:nbn:hr:264:148910

Flegar Meštrić, Zlata, Mirjana Mariana Kardum Paro, Sonja Perkov, Vinko Vidjak and Marija Grdić Rajković. "Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis." In Atherogenesis, edited by Sampath Parrthasarathy, 507-528. INTECHWEB.ORG: InTech, 2012. https://urn.nsk.hr/urn:nbn:hr:264:148910

Flegar Meštrić, Z., et al. (2012) 'Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis' in Parrthasarathy, S. (ed.) Atherogenesis INTECHWEB.ORG: InTech, pp. 507-528. Available at: https://urn.nsk.hr/urn:nbn:hr:264:148910 (Accessed 22 November 2024)

Flegar Meštrić Z, Kardum Paro MM, Perkov S, Vidjak V, Grdić Rajković M. Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis. In: S. Parrthasarathy, ed. Atherogenesis. INTECHWEB.ORG: InTech; 2012. Pp. 507-528. [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:264:148910

Z. Flegar Meštrić, M. M. Kardum Paro, S. Perkov, V. Vidjak and M. Grdić Rajković, "Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis", Atherogenesis, S. Parrthasarathy, Ed. INTECHWEB.ORG: InTech, 2012, pp. 507-528. [Online] Available at: https://urn.nsk.hr/urn:nbn:hr:264:148910

Metadata
Title (english)Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
AuthorZlata Flegar-Meštrić
AuthorMirjana Mariana Kardum Paro
AuthorSonja Perkov
AuthorVinko Vidjak
AuthorMarija Grdić Rajković
EditorSampath Parrthasarathy
Author's institution(Merkur University Hospital)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The results of the present study show that basal and stimulated PON1 activities were significantly decreased in patient’s group with cerebrovascular stenosis ( group of patients with symptoms of cerebrovascular insufficiency and stenosis of carotid artery more than 50% of the lumen) versus control no-stenosis group (p<0.05). There were no statistically significant relationships between PON1 activity and lipid parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol and tryacilglycerols), p>0.05. According to the obtained results the decreased PON1 activities in patients with cerebrovascular stenosis may cause decreased HDL antioxidant capacity and therefore contribute to the increase risk of the development of cerebrovascular atherosclerosis.However, there were no significant differences in genotype or allele frequencies of pon1 and pon2 genes between patients with stenosis of cerebral arteries and no-stenosis control group indicating that changes in paraoxonase activity are determined by both genetic and environmental factors. Our results show the most significant linear relationship between PAF-AH activity and total cholesterol and LDL-cholesterol ( p<0.001) in control no-stenosis group as well as in the group of patients with cerebrovascular stenosis. The median serum PAF-AH activity did not differ significantly between patients with cerebrovascular stenosis and control no-stenosis group (p>0, 05) while LDL standardized PAF-AH activity showed significant difference between both examined groups (p<0.0001). According to our results the LDL-standardized PAF-AH activity could be used as an additional discriminating biochemical indicator of cerebrovascular stenosis
Keywords (english)
Languageenglish
Publication typeScientific paper - Chapter in Book
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Book titleAtherogenesis
Numberingpp. 507-528
ISBN978-953-307-992-9
URN:NBNurn:nbn:hr:264:148910
Publication2012-01
ProjectNumber: 044-0061245-0551
Title (croatian): Novi biokemijski biljezi ateroskleroze u krvožilnim bolestima
Leader: Flegar-Meštrić, Zlata
Jurisdiction: Croatia
Funding stream: 0,00 EUR
Document URLhttps://www.intechopen.com/books/atherogenesis
Type of resourceText
PublisherInTech
Publishing placeINTECHWEB.ORG
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-05-27 10:27:21